biostudies-literatureUnknown16Kim K<h4>Background</h4>Studies on the risk and protective factors for lung function decline and mortality in rheumatoid arthritis-related interstitial lung disease (RA-ILD) are limited.<h4>Objectives</h4>We aimed to investigate clinical factors and medication uses associated with lung function decline and mortality in RA-ILD.<h4>Methods</h4>This retrospective cohort study examined the medical records of patients with RA-ILD who visited Severance Hospital between January 2006 and December 2019. We selected 170 patients with RA-ILD who had undergone at least one spirometry test and chest computed tomography scan. An absolute decline of ⩾10% in the functional vital capacity (FVC) was defined as significant decline in pulmonary function. Data for analysis were retrieved from electronic medical recTherapeutic advances in respiratory disease17534666221135314https://www.ebi.ac.uk/biostudies/studies/S-EPMC9647291biostudies-literatureProtective effect of methotrexate on lung function and mortality in rheumatoid arthritis-related interstitial lung disease: a retrospective cohort study.PMC9647291Kim SYLeem AYChung KSWoo ALee SHKim KPark MSKang YAKim EYPark YYong SHJung JYKim YSfalseProtective effect of methotrexate on lung function and mortality in rheumatoid arthritis-related interstitial lung disease: a retrospective cohort study.<h4>Background</h4>Studies on the risk and protective factors for lung function decline and mortality in rheumatoid arthritis-related interstitial lung disease (RA-ILD) are limited.<h4>Objectives</h4>We aimed to investigate clinical factors and medication uses associated with lung function decline and mortality in RA-ILD.<h4>Methods</h4>This retrospective cohort study examined the medical records of patients with RA-ILD who visited Severance Hospital between January 2006 and December 2019. We selected 170 patients with RA-ILD who had undergone at least one spirometry test and chest computed tomography scan. An absolute decline of ⩾10% in the functional vital capacity (FVC) was defined as significant decline in pulmonary function. Data for analysis were retrieved from electronic medical rec2022-01-01T00:00:00Z2022 Jan-Dec2025-04-19T10:40:09.889Z2025-04-19T10:40:09.889ZS-EPMC96472913634607610.1177/17534666221135314