{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chao HC"],"funding":["National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["704-713"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9648535"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(4)"],"pubmed_abstract":["A hallmark of electrospray ionization (ESI) of large polymeric molecules is its tendency to generate charge state distributions. When a distribution of polymers is subjected to ESI, the charge state distribution of each component can lead to a mass spectrum composed of a highly congested mixture of ions with overlapping mass-to-charge (<i>m</i>/<i>z</i>) ratios. When the polymers are composed of a common monomeric unit (i.e., a homopolymer), the overlap of the charge state distributions of the polymer components can give rise to striking spectral patterns with a dense central cluster of peaks having similar <i>m</i>/<i>z</i> values and wing-like patterns on either side. We refer to the central cluster of peaks as an \"Emerald City,\" with a nod to the Wizard of Oz, combining the wings as an "],"journal":["Journal of the American Society for Mass Spectrometry"],"pubmed_title":["Characterization of Homopolymer Distributions via Direct Infusion ESI-MS/MS using Wide Mass-to-Charge Windows and Gas-Phase Ion/Ion Reactions."],"pmcid":["PMC9648535"],"funding_grant_id":["R37 GM045372","R37-GM45372"],"pubmed_authors":["McLuckey SA","Chao HC","Shih M","Lee KW"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of Homopolymer Distributions via Direct Infusion ESI-MS/MS using Wide Mass-to-Charge Windows and Gas-Phase Ion/Ion Reactions.","description":"A hallmark of electrospray ionization (ESI) of large polymeric molecules is its tendency to generate charge state distributions. When a distribution of polymers is subjected to ESI, the charge state distribution of each component can lead to a mass spectrum composed of a highly congested mixture of ions with overlapping mass-to-charge (<i>m</i>/<i>z</i>) ratios. When the polymers are composed of a common monomeric unit (i.e., a homopolymer), the overlap of the charge state distributions of the polymer components can give rise to striking spectral patterns with a dense central cluster of peaks having similar <i>m</i>/<i>z</i> values and wing-like patterns on either side. We refer to the central cluster of peaks as an \"Emerald City,\" with a nod to the Wizard of Oz, combining the wings as an ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-05T11:27:37.272Z","creation":"2025-04-05T11:27:37.272Z"},"accession":"S-EPMC9648535","cross_references":{"pubmed":["35201770"],"doi":["10.1021/jasms.2c00001"]}}