{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["30(10)"],"submitter":["Aleem A"],"pubmed_abstract":["<h4>Introduction</h4>Diabetes mellitus causes hyperglycemia and associated complications to the brain. In current study, the traditionally reported remedial claims of <i>Agave americana</i> var. <i>marginata</i> has been scientifically investigated in diabetic rats.<h4>Methodology</h4>The methanolic extract of leaves of Agave <i>americana</i> var. <i>marginata</i> (Aa.Cr) was characterized for total phenols, flavonoids, and antioxidant potential through <i>in-vitro</i> testing. The rats chronically pre-treated with Aa.Cr (400 and 600 mg/kg) for 45 days were challenged with alloxan-induced hyperglycemia. The dose-dependent effects of Aa.Cr on blood glucose levels and body weights were compared with diabetic rats using glibenclamide (0.6 mg/kg) as a standard. The animals were tested for diab"],"journal":["Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society"],"pagination":["1373-1386"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9649343"],"repository":["biostudies-literature"],"pubmed_title":["Chronically administered <i>Agave americana var</i>. marginata extract ameliorates diabetes mellitus, associated behavioral comorbidities and biochemical parameters in alloxan-induced diabetic rats."],"pmcid":["PMC9649343"],"pubmed_authors":["Rasool MF","Alqahtani F","Shahnaz S","F Alotaibi A","Javaid S","Ahmad T","Aleem A","Ashraf W","Albeshri KS","Imran I"],"additional_accession":[]},"is_claimable":false,"name":"Chronically administered <i>Agave americana var</i>. marginata extract ameliorates diabetes mellitus, associated behavioral comorbidities and biochemical parameters in alloxan-induced diabetic rats.","description":"<h4>Introduction</h4>Diabetes mellitus causes hyperglycemia and associated complications to the brain. In current study, the traditionally reported remedial claims of <i>Agave americana</i> var. <i>marginata</i> has been scientifically investigated in diabetic rats.<h4>Methodology</h4>The methanolic extract of leaves of Agave <i>americana</i> var. <i>marginata</i> (Aa.Cr) was characterized for total phenols, flavonoids, and antioxidant potential through <i>in-vitro</i> testing. The rats chronically pre-treated with Aa.Cr (400 and 600 mg/kg) for 45 days were challenged with alloxan-induced hyperglycemia. The dose-dependent effects of Aa.Cr on blood glucose levels and body weights were compared with diabetic rats using glibenclamide (0.6 mg/kg) as a standard. The animals were tested for diab","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-05T11:36:15.25Z","creation":"2025-04-05T11:36:15.25Z"},"accession":"S-EPMC9649343","cross_references":{"pubmed":["36387342"],"doi":["10.1016/j.jsps.2022.06.003"]}}