biostudies-literatureUnknown30(10)Aleem A<h4>Introduction</h4>Diabetes mellitus causes hyperglycemia and associated complications to the brain. In current study, the traditionally reported remedial claims of <i>Agave americana</i> var. <i>marginata</i> has been scientifically investigated in diabetic rats.<h4>Methodology</h4>The methanolic extract of leaves of Agave <i>americana</i> var. <i>marginata</i> (Aa.Cr) was characterized for total phenols, flavonoids, and antioxidant potential through <i>in-vitro</i> testing. The rats chronically pre-treated with Aa.Cr (400 and 600 mg/kg) for 45 days were challenged with alloxan-induced hyperglycemia. The dose-dependent effects of Aa.Cr on blood glucose levels and body weights were compared with diabetic rats using glibenclamide (0.6 mg/kg) as a standard. The animals were tested for diabSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society1373-1386https://www.ebi.ac.uk/biostudies/studies/S-EPMC9649343biostudies-literatureChronically administered <i>Agave americana var</i>. marginata extract ameliorates diabetes mellitus, associated behavioral comorbidities and biochemical parameters in alloxan-induced diabetic rats.PMC9649343Rasool MFAlqahtani FShahnaz SF Alotaibi AJavaid SAhmad TAleem AAshraf WAlbeshri KSImran IfalseChronically administered <i>Agave americana var</i>. marginata extract ameliorates diabetes mellitus, associated behavioral comorbidities and biochemical parameters in alloxan-induced diabetic rats.<h4>Introduction</h4>Diabetes mellitus causes hyperglycemia and associated complications to the brain. In current study, the traditionally reported remedial claims of <i>Agave americana</i> var. <i>marginata</i> has been scientifically investigated in diabetic rats.<h4>Methodology</h4>The methanolic extract of leaves of Agave <i>americana</i> var. <i>marginata</i> (Aa.Cr) was characterized for total phenols, flavonoids, and antioxidant potential through <i>in-vitro</i> testing. The rats chronically pre-treated with Aa.Cr (400 and 600 mg/kg) for 45 days were challenged with alloxan-induced hyperglycemia. The dose-dependent effects of Aa.Cr on blood glucose levels and body weights were compared with diabetic rats using glibenclamide (0.6 mg/kg) as a standard. The animals were tested for diab2022-01-01T00:00:00Z2022 Oct2025-04-05T11:36:15.25Z2025-04-05T11:36:15.25ZS-EPMC96493433638734210.1016/j.jsps.2022.06.003