biostudies-literatureUnknown8(11)Mahmood WSynthesis of new Cefpodoxime derivatives via Schiff Bases mechanism and the efficiency of their antimicrobial and antiviral activities were addressed. They were analyzed for structural validation by using spectroscopic techniques using FTIR, 1HNMR, and 13CNMR. Molecular docking against IBV Virus papain-like protease (PLPro) was done with Auto dock tools against compounds having excellent IC50 values against IBV (Corona Class) virus. All derivatives showed strong zone of inhibition ranges from (55 ± 2.0 to 70 ± 0.8 mm) against E. coli. Compounds 1,2,4 and 6 derivatives showed remarkable activity against Stenotrophomonas maltophilia and Serratia marcescens. But For most the newly synthesized derivatives C 1 (64 ± Heliyone11332https://www.ebi.ac.uk/biostudies/studies/S-EPMC9649975biostudies-literatureSynthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime.PMC9649975Shahzad MISajid-Ur-Rehman MPervaiz IKhurshid UAhmad IAli Shah SAAshraf MMahmood WKhan MAfalseSynthesis, characterization, molecular docking and biological evaluation of Schiff Base derivatives of cefpodoxime.Synthesis of new Cefpodoxime derivatives via Schiff Bases mechanism and the efficiency of their antimicrobial and antiviral activities were addressed. They were analyzed for structural validation by using spectroscopic techniques using FTIR, 1HNMR, and 13CNMR. Molecular docking against IBV Virus papain-like protease (PLPro) was done with Auto dock tools against compounds having excellent IC50 values against IBV (Corona Class) virus. All derivatives showed strong zone of inhibition ranges from (55 ± 2.0 to 70 ± 0.8 mm) against E. coli. Compounds 1,2,4 and 6 derivatives showed remarkable activity against Stenotrophomonas maltophilia and Serratia marcescens. But For most the newly synthesized derivatives C 1 (64 ± 2022-01-01T00:00:00Z2022 Nov2025-05-29T16:11:25.445Z2025-04-06T01:49:43.848ZS-EPMC96499753638745010.1016/j.heliyon.2022.e11332