{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang H"],"funding":["Basic Energy Sciences","National Science Foundation"],"pagination":["20221-20226"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9650692"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["144(44)"],"pubmed_abstract":["Pore space partitioning (PSP) is methodically suited for dramatically increasing the density of guest binding sites, leading to the partitioned acs (pacs) platform capable of record-high uptake for CO<sub>2</sub> and small hydrocarbons such as C<sub>2</sub>H<sub><i>x</i></sub>. For gas separation, achieving high selectivity amid PSP-enabled high uptake offers an enticing prospect. Here we aim for high selectivity by introducing the bioisosteric (BIS) concept, a widely used drug design strategy, into the realm of pore-space-partitioned MOFs. New pacs materials have high C<sub>2</sub>H<sub>2</sub>/CO<sub>2</sub> selectivity of up to 29, high C<sub>2</sub>H<sub>2</sub> uptake of up to 144 cm<sup>3</sup>/g (298 K, 1 atm), and high separation potential of up to 5.3 mmol/g, leading to excellent "],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Optimization of Pore-Space-Partitioned Metal-Organic Frameworks Using the Bioisosteric Concept."],"pmcid":["PMC9650692"],"funding_grant_id":["2105961","2117040","DE-SC0010596"],"pubmed_authors":["Yang H","Bu X","Hong AN","Chen Y","Dang C","Feng P"],"additional_accession":[]},"is_claimable":false,"name":"Optimization of Pore-Space-Partitioned Metal-Organic Frameworks Using the Bioisosteric Concept.","description":"Pore space partitioning (PSP) is methodically suited for dramatically increasing the density of guest binding sites, leading to the partitioned acs (pacs) platform capable of record-high uptake for CO<sub>2</sub> and small hydrocarbons such as C<sub>2</sub>H<sub><i>x</i></sub>. For gas separation, achieving high selectivity amid PSP-enabled high uptake offers an enticing prospect. Here we aim for high selectivity by introducing the bioisosteric (BIS) concept, a widely used drug design strategy, into the realm of pore-space-partitioned MOFs. New pacs materials have high C<sub>2</sub>H<sub>2</sub>/CO<sub>2</sub> selectivity of up to 29, high C<sub>2</sub>H<sub>2</sub> uptake of up to 144 cm<sup>3</sup>/g (298 K, 1 atm), and high separation potential of up to 5.3 mmol/g, leading to excellent ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T09:02:37.773Z","creation":"2025-04-04T09:02:37.773Z"},"accession":"S-EPMC9650692","cross_references":{"pubmed":["36305830"],"doi":["10.1021/jacs.2c09349"]}}