{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["De Luca C"],"pubmed_abstract":["Fowl adenovirus (FAdV)-induced diseases hepatitis-hydropericardium syndrome (HHS) and inclusion body hepatitis (IBH) have been affecting the poultry industry with increasing severity in the last two decades. Recently, a subunit vaccine based on a chimeric fiber protein with epitopes from different fowl adenovirus serotypes (named crecFib-4/11) has been shown to confer simultaneous protection against both HHS and IBH. However, the underlying immune mechanisms in chickens are still enigmatic, especially because of frequently absent neutralizing response despite high levels of protection. In this study, we investigated the kinetics of the humoral and cellular immune responses in specific pathogen-free chickens after vaccination with crecFib-4/11 and/or challenge with a HHS-causing strain, on "],"journal":["Frontiers in immunology"],"pagination":["1026233"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9650998"],"repository":["biostudies-literature"],"pubmed_title":["Local cellular immune response plays a key role in protecting chickens against hepatitis-hydropericardium syndrome (HHS) by vaccination with a recombinant fowl adenovirus (FAdV) chimeric fiber protein."],"pmcid":["PMC9650998"],"pubmed_authors":["De Luca C","Schachner A","Liebhart D","Heidl S","Hess M","Mitra T"],"additional_accession":[]},"is_claimable":false,"name":"Local cellular immune response plays a key role in protecting chickens against hepatitis-hydropericardium syndrome (HHS) by vaccination with a recombinant fowl adenovirus (FAdV) chimeric fiber protein.","description":"Fowl adenovirus (FAdV)-induced diseases hepatitis-hydropericardium syndrome (HHS) and inclusion body hepatitis (IBH) have been affecting the poultry industry with increasing severity in the last two decades. Recently, a subunit vaccine based on a chimeric fiber protein with epitopes from different fowl adenovirus serotypes (named crecFib-4/11) has been shown to confer simultaneous protection against both HHS and IBH. However, the underlying immune mechanisms in chickens are still enigmatic, especially because of frequently absent neutralizing response despite high levels of protection. In this study, we investigated the kinetics of the humoral and cellular immune responses in specific pathogen-free chickens after vaccination with crecFib-4/11 and/or challenge with a HHS-causing strain, on ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-27T18:49:58.834Z","creation":"2025-02-19T04:07:21.593Z"},"accession":"S-EPMC9650998","cross_references":{"pubmed":["36389772"],"doi":["10.3389/fimmu.2022.1026233"]}}