{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Li J"],"pubmed_abstract":["The sarcoendoplasmic reticulum calcium adenosine triphosphatase (ATPase) 3 (<i>SERCA3</i>), a member of the SERCA protein family, is located at the endoplasmic reticulum. Its main function is to pump Ca2+ into the endoplasmic reticulum and is involved in maintaining intracellular calcium homeostasis and signal transduction, which are very important factors impacting cancer development and progression. However, the specific role of <i>SERCA3</i> in cancer remains unclear. Our study, for the first time, comprehensively analyzed the <i>SERCA3</i> expression profile in multiple cancers and its prognostic value in different cancers using bioinformatics. Furthermore, TCGA database was applied to evaluate the certain correlation of <i>SERCA3</i> expression with immune modulator genes, immune chec"],"journal":["Journal of oncology"],"pagination":["9359879"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9652089"],"repository":["biostudies-literature"],"pubmed_title":["Role of <i>SERCA3</i> in the Prognosis and Immune Function in Pan-Cancer."],"pmcid":["PMC9652089"],"pubmed_authors":["Jiang Y","Li X","Li J","Tao L","Xie Y","Huang H","Zhang C"],"additional_accession":[]},"is_claimable":false,"name":"Role of <i>SERCA3</i> in the Prognosis and Immune Function in Pan-Cancer.","description":"The sarcoendoplasmic reticulum calcium adenosine triphosphatase (ATPase) 3 (<i>SERCA3</i>), a member of the SERCA protein family, is located at the endoplasmic reticulum. Its main function is to pump Ca2+ into the endoplasmic reticulum and is involved in maintaining intracellular calcium homeostasis and signal transduction, which are very important factors impacting cancer development and progression. However, the specific role of <i>SERCA3</i> in cancer remains unclear. Our study, for the first time, comprehensively analyzed the <i>SERCA3</i> expression profile in multiple cancers and its prognostic value in different cancers using bioinformatics. Furthermore, TCGA database was applied to evaluate the certain correlation of <i>SERCA3</i> expression with immune modulator genes, immune chec","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-25T23:21:58.807Z","creation":"2025-04-06T09:20:39.336Z"},"accession":"S-EPMC9652089","cross_references":{"pubmed":["36385955"],"doi":["10.1155/2022/9359879"]}}