biostudies-literatureUnknown2022Li JThe sarcoendoplasmic reticulum calcium adenosine triphosphatase (ATPase) 3 (<i>SERCA3</i>), a member of the SERCA protein family, is located at the endoplasmic reticulum. Its main function is to pump Ca2+ into the endoplasmic reticulum and is involved in maintaining intracellular calcium homeostasis and signal transduction, which are very important factors impacting cancer development and progression. However, the specific role of <i>SERCA3</i> in cancer remains unclear. Our study, for the first time, comprehensively analyzed the <i>SERCA3</i> expression profile in multiple cancers and its prognostic value in different cancers using bioinformatics. Furthermore, TCGA database was applied to evaluate the certain correlation of <i>SERCA3</i> expression with immune modulator genes, immune checJournal of oncology9359879https://www.ebi.ac.uk/biostudies/studies/S-EPMC9652089biostudies-literatureRole of <i>SERCA3</i> in the Prognosis and Immune Function in Pan-Cancer.PMC9652089Jiang YLi XLi JTao LXie YHuang HZhang CfalseRole of <i>SERCA3</i> in the Prognosis and Immune Function in Pan-Cancer.The sarcoendoplasmic reticulum calcium adenosine triphosphatase (ATPase) 3 (<i>SERCA3</i>), a member of the SERCA protein family, is located at the endoplasmic reticulum. Its main function is to pump Ca2+ into the endoplasmic reticulum and is involved in maintaining intracellular calcium homeostasis and signal transduction, which are very important factors impacting cancer development and progression. However, the specific role of <i>SERCA3</i> in cancer remains unclear. Our study, for the first time, comprehensively analyzed the <i>SERCA3</i> expression profile in multiple cancers and its prognostic value in different cancers using bioinformatics. Furthermore, TCGA database was applied to evaluate the certain correlation of <i>SERCA3</i> expression with immune modulator genes, immune chec2022-01-01T00:00:00Z20222025-04-25T23:21:58.807Z2025-04-06T09:20:39.336ZS-EPMC96520893638595510.1155/2022/9359879