{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(12)"],"submitter":["Hans D"],"funding":["University of Lausanne","Amgen"],"pubmed_abstract":["TBS algorithm has been updated to account for regional soft tissue noise. In postmenopausal women with osteoporosis, denosumab improved tissue thickness-adjusted TBS vs placebo independently of bone mineral density over 3 years, with the magnitude of changes from baseline or placebo numerically greater than body mass index-adjusted TBS.<h4>Introduction</h4>To evaluate the effect of denosumab on bone microarchitecture assessed by trabecular bone score (TBS) in the FREEDOM study using the updated algorithm that accounts for regional soft tissue thickness (TBS<sub>TT</sub>) in dual-energy X-ray absorptiometry (DXA) images and to compare percent changes from baseline and placebo with classical body mass index (BMI)-adjusted TBS (TBS<sub>BMI</sub>).<h4>Methods</h4>Postmenopausal women with lumb"],"journal":["Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA"],"pagination":["2517-2525"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9652244"],"repository":["biostudies-literature"],"pubmed_title":["Updated trabecular bone score accounting for the soft tissue thickness (TBS<sub>TT</sub>) demonstrated significantly improved bone microstructure with denosumab in the FREEDOM TBS post hoc analysis."],"pmcid":["PMC9652244"],"pubmed_authors":["Huang S","Hans D","Shevroja E","McClung M","McDermott M","Kim M"],"additional_accession":[]},"is_claimable":false,"name":"Updated trabecular bone score accounting for the soft tissue thickness (TBS<sub>TT</sub>) demonstrated significantly improved bone microstructure with denosumab in the FREEDOM TBS post hoc analysis.","description":"TBS algorithm has been updated to account for regional soft tissue noise. In postmenopausal women with osteoporosis, denosumab improved tissue thickness-adjusted TBS vs placebo independently of bone mineral density over 3 years, with the magnitude of changes from baseline or placebo numerically greater than body mass index-adjusted TBS.<h4>Introduction</h4>To evaluate the effect of denosumab on bone microarchitecture assessed by trabecular bone score (TBS) in the FREEDOM study using the updated algorithm that accounts for regional soft tissue thickness (TBS<sub>TT</sub>) in dual-energy X-ray absorptiometry (DXA) images and to compare percent changes from baseline and placebo with classical body mass index (BMI)-adjusted TBS (TBS<sub>BMI</sub>).<h4>Methods</h4>Postmenopausal women with lumb","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-19T18:51:16.241Z","creation":"2025-04-19T18:51:16.241Z"},"accession":"S-EPMC9652244","cross_references":{"pubmed":["36115888"],"doi":["10.1007/s00198-022-06549-x"]}}