biostudies-literatureUnknown33(12)Hans DUniversity of LausanneAmgenTBS algorithm has been updated to account for regional soft tissue noise. In postmenopausal women with osteoporosis, denosumab improved tissue thickness-adjusted TBS vs placebo independently of bone mineral density over 3 years, with the magnitude of changes from baseline or placebo numerically greater than body mass index-adjusted TBS.<h4>Introduction</h4>To evaluate the effect of denosumab on bone microarchitecture assessed by trabecular bone score (TBS) in the FREEDOM study using the updated algorithm that accounts for regional soft tissue thickness (TBS_TT) in dual-energy X-ray absorptiometry (DXA) images and to compare percent changes from baseline and placebo with classical body mass index (BMI)-adjusted TBS (TBS_BMI).<h4>Methods</h4>Postmenopausal women with lumbOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2517-2525https://www.ebi.ac.uk/biostudies/studies/S-EPMC9652244biostudies-literatureUpdated trabecular bone score accounting for the soft tissue thickness (TBS_TT) demonstrated significantly improved bone microstructure with denosumab in the FREEDOM TBS post hoc analysis.PMC9652244Huang SHans DShevroja EMcClung MMcDermott MKim MfalseUpdated trabecular bone score accounting for the soft tissue thickness (TBS_TT) demonstrated significantly improved bone microstructure with denosumab in the FREEDOM TBS post hoc analysis.TBS algorithm has been updated to account for regional soft tissue noise. In postmenopausal women with osteoporosis, denosumab improved tissue thickness-adjusted TBS vs placebo independently of bone mineral density over 3 years, with the magnitude of changes from baseline or placebo numerically greater than body mass index-adjusted TBS.<h4>Introduction</h4>To evaluate the effect of denosumab on bone microarchitecture assessed by trabecular bone score (TBS) in the FREEDOM study using the updated algorithm that accounts for regional soft tissue thickness (TBS_TT) in dual-energy X-ray absorptiometry (DXA) images and to compare percent changes from baseline and placebo with classical body mass index (BMI)-adjusted TBS (TBS_BMI).<h4>Methods</h4>Postmenopausal women with lumb2022-01-01T00:00:00Z2022 Dec2025-04-19T18:51:16.241Z2025-04-19T18:51:16.241ZS-EPMC96522443611588810.1007/s00198-022-06549-x