biostudies-literatureUnknown6(1)Wang TRecurrent fusions of receptor tyrosine kinases (RTKs) are often driving events in tumorigenesis that carry important diagnostic value and are potentially targetable by the increasing number of tyrosine kinase inhibitors (TKIs). Here, we characterized the spectrum of 1324 RTK fusions with intact kinase domains in solid tumors by DNA-based high-throughput sequencing. Overall, the prevalence of RTK fusions were 4.7%, with variable frequencies and diverse genomic structures and fusion partners across cancer types. Cancer types, such as thyroid cancers, urological cancers and neuroendocrine tumors are selective in the RTK fusions they carry, while others exhibit highly complex spectra of fusion events. Notably, most RTKs were promiscuous in terms of the partner genes they recombine with. A largNPJ precision oncology84https://www.ebi.ac.uk/biostudies/studies/S-EPMC9652465biostudies-literatureLandscape of potentially targetable receptor tyrosine kinase fusions in diverse cancers by DNA-based profiling.PMC9652465Yin JCShao YChen ZWang SWang TYou SWang ZWei LLu QfalseLandscape of potentially targetable receptor tyrosine kinase fusions in diverse cancers by DNA-based profiling.Recurrent fusions of receptor tyrosine kinases (RTKs) are often driving events in tumorigenesis that carry important diagnostic value and are potentially targetable by the increasing number of tyrosine kinase inhibitors (TKIs). Here, we characterized the spectrum of 1324 RTK fusions with intact kinase domains in solid tumors by DNA-based high-throughput sequencing. Overall, the prevalence of RTK fusions were 4.7%, with variable frequencies and diverse genomic structures and fusion partners across cancer types. Cancer types, such as thyroid cancers, urological cancers and neuroendocrine tumors are selective in the RTK fusions they carry, while others exhibit highly complex spectra of fusion events. Notably, most RTKs were promiscuous in terms of the partner genes they recombine with. A larg2022-01-01T00:00:00Z2022 Nov2025-04-25T23:25:27.01Z2025-02-19T00:31:54.026ZS-EPMC96524653636947410.1038/s41698-022-00325-0