{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(20)"],"submitter":["Zeng R"],"pubmed_abstract":["<h4>Background</h4>Lymphopenia at diagnosis is considered a negative prognostic factor for patients with extra-nodal natural killer (NK)/T-cell lymphoma (ENKTL), especially that of the absolute cluster of differentiation 4<sup>+</sup> T cell count (ACD4C), which has previously been identified as an independent prognostic factor in other hematologic malignancies. However, there is limited data available regarding the prognostic value of peripheral blood T lymphocyte subsets in ENKTL patients. The purpose of this study was to investigate the prognostic value of lymphocyte subsets, especially the ACD4C in ENKTL as a clinical biomarker.<h4>Methods</h4>We analyzed the clinical data of 176 patients who met the inclusion criteria in Cancer Center of Integrated Hospital of Traditional Chinese Medi"],"journal":["Annals of translational medicine"],"pagination":["1119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9652555"],"repository":["biostudies-literature"],"pubmed_title":["Low absolute CD4<sup>+</sup> T cell counts in peripheral blood: an independent predictor of inferior survival in natural killer/T-cell lymphoma-a retrospective cohort study."],"pmcid":["PMC9652555"],"pubmed_authors":["Zeng R","Xia Y","Jiang L","Bai B","Alpdogan O","Li P","Dalia S","Janetos TM","Shikama N","Zhu L","Gao Y","Zhu X","Zhu W","Wang X"],"additional_accession":[]},"is_claimable":false,"name":"Low absolute CD4<sup>+</sup> T cell counts in peripheral blood: an independent predictor of inferior survival in natural killer/T-cell lymphoma-a retrospective cohort study.","description":"<h4>Background</h4>Lymphopenia at diagnosis is considered a negative prognostic factor for patients with extra-nodal natural killer (NK)/T-cell lymphoma (ENKTL), especially that of the absolute cluster of differentiation 4<sup>+</sup> T cell count (ACD4C), which has previously been identified as an independent prognostic factor in other hematologic malignancies. However, there is limited data available regarding the prognostic value of peripheral blood T lymphocyte subsets in ENKTL patients. The purpose of this study was to investigate the prognostic value of lymphocyte subsets, especially the ACD4C in ENKTL as a clinical biomarker.<h4>Methods</h4>We analyzed the clinical data of 176 patients who met the inclusion criteria in Cancer Center of Integrated Hospital of Traditional Chinese Medi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-25T23:28:15.221Z","creation":"2025-04-06T09:21:30.723Z"},"accession":"S-EPMC9652555","cross_references":{"pubmed":["36388826"],"doi":["10.21037/atm-22-4846"]}}