biostudies-literatureUnknown10(20)Zeng R<h4>Background</h4>Lymphopenia at diagnosis is considered a negative prognostic factor for patients with extra-nodal natural killer (NK)/T-cell lymphoma (ENKTL), especially that of the absolute cluster of differentiation 4⁺ T cell count (ACD4C), which has previously been identified as an independent prognostic factor in other hematologic malignancies. However, there is limited data available regarding the prognostic value of peripheral blood T lymphocyte subsets in ENKTL patients. The purpose of this study was to investigate the prognostic value of lymphocyte subsets, especially the ACD4C in ENKTL as a clinical biomarker.<h4>Methods</h4>We analyzed the clinical data of 176 patients who met the inclusion criteria in Cancer Center of Integrated Hospital of Traditional Chinese MediAnnals of translational medicine1119https://www.ebi.ac.uk/biostudies/studies/S-EPMC9652555biostudies-literatureLow absolute CD4⁺ T cell counts in peripheral blood: an independent predictor of inferior survival in natural killer/T-cell lymphoma-a retrospective cohort study.PMC9652555Zeng RXia YJiang LBai BAlpdogan OLi PDalia SJanetos TMShikama NZhu LGao YZhu XZhu WWang XfalseLow absolute CD4⁺ T cell counts in peripheral blood: an independent predictor of inferior survival in natural killer/T-cell lymphoma-a retrospective cohort study.<h4>Background</h4>Lymphopenia at diagnosis is considered a negative prognostic factor for patients with extra-nodal natural killer (NK)/T-cell lymphoma (ENKTL), especially that of the absolute cluster of differentiation 4⁺ T cell count (ACD4C), which has previously been identified as an independent prognostic factor in other hematologic malignancies. However, there is limited data available regarding the prognostic value of peripheral blood T lymphocyte subsets in ENKTL patients. The purpose of this study was to investigate the prognostic value of lymphocyte subsets, especially the ACD4C in ENKTL as a clinical biomarker.<h4>Methods</h4>We analyzed the clinical data of 176 patients who met the inclusion criteria in Cancer Center of Integrated Hospital of Traditional Chinese Medi2022-01-01T00:00:00Z2022 Oct2025-04-25T23:28:15.221Z2025-04-06T09:21:30.723ZS-EPMC96525553638882610.21037/atm-22-4846