biostudies-literatureKalman JLUniversitätsklinik MünchenSee Supplementary Material for a detailed list of funding sources1611-1620https://www.ebi.ac.uk/biostudies/studies/S-EPMC9653330biostudies-literatureUnknown272(8)Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (N = 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on European archives of psychiatry and clinical neuroscienceInvestigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses.PMC9653330See Supplementary Material for a detailed list of funding sourcesMcCarthy MJOzaki NRepple JBanzato CEMCichon SHoban RBaune BTMitjans MVieta EKahn JPBauer MTwarowska-Hauser JWright AThomas-Odenthal FAkiyama KChen HCZandi PPJamain SGrotegerd DSquassina AThiel KLeboyer MKusumi IBrosch KChillotti CMeller TRingwald KGDantas CBacklund LJaramillo CALPapiol SMitchell PBNovak THauser JSeymour LRColom FHahn TTurecki GStopkova PHoffmann PPerlis RHAlda MHasler RRybakowski JKKittel-Schneider SGruber OMeinert SFullerton JDePaulo JRNenadic ISeemuller FManchia MHashimoto RCousins DStein FKapelski PNothen MFrisen LNallet ALeckband SGYoshida TSchweizer BAdorjan KGard SGrof PCzerski PMSchulze TGSchofield PRDannlowski UObregia ADePaulo RJDetera-Wadleigh SDReif AKelsoe JRGoes FSOsby UReininghaus ERietschel MMaj MNothen MMMonteleone PKohshour MOSenner FDayer ABudde MSmoller JWLaje GSchalling MStreit FGrigoroiu-Serbanescu MBiernacka JMDel Zompo MGarnham JSchulte ECSchaupp SPfennig ASteele JPawlak JYoung LTSeverino GAdli MArdau RHeilmann-Heimbach SHeilbronner UMasui TMTOpel NHeilbronner MRouleau GWray NRKliwicki SReich-Erkelenz DForstner AMasui TConsortium on Lithium Genetics (ConLiGen), PsyCourseAndlauer TFMFalkai PBrichant-Petitjean CSlaney CDegenhardt FBenabarre AMartinsson LKassem LCzerski PAkula NLavebratt CFrye MACruceanu CPfarr JKTortorella AMcMahon FJKato TAubry JMHou LEtain BJimenez EPotash JBStamm TTighe SKalman JLBui ETBengesser SAMacQueen GRichard-Lepouriel HWinter AKircher TArias BfalseInvestigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses.Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (N = 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on 2022-01-01T00:00:00Z2022 Dec2025-04-05T15:42:19.092Z2025-04-05T15:42:19.092ZS-EPMC96533303514657110.1007/s00406-021-01366-5