{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Lee YB"],"pubmed_abstract":["We explored the association between cholesterol levels and dementia risk according to the presence of diabetes and statin use. In this population-based longitudinal cohort study, the Korean National Health Insurance Service datasets (2002-2017) were used. Among individuals aged ≥ 40 years who underwent health examinations in 2009 (N = 6,883,494), the hazard of dementia was evaluated according to cholesterol levels. During a median 8.33 years, 263,185 dementia cases were detected. In statin non-users with or without diabetes, the hazards of all-cause dementia were highest for those in the lowest quartile or quintile of low-density lipoprotein-cholesterol (LDL-C) level, showing an inverted J-shaped relationship. Among statin users with or without diabetes, an advance in LDL-C group was assoc"],"journal":["Scientific reports"],"pagination":["19383"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9653412"],"repository":["biostudies-literature"],"pubmed_title":["Association between cholesterol levels and dementia risk according to the presence of diabetes and statin use: a nationwide cohort study."],"pmcid":["PMC9653412"],"pubmed_authors":["Lee YB","Kim B","Han K","Park J","Kim G","Kim MY","Hur KY","Kim JH","Jin SM"],"additional_accession":[]},"is_claimable":false,"name":"Association between cholesterol levels and dementia risk according to the presence of diabetes and statin use: a nationwide cohort study.","description":"We explored the association between cholesterol levels and dementia risk according to the presence of diabetes and statin use. In this population-based longitudinal cohort study, the Korean National Health Insurance Service datasets (2002-2017) were used. Among individuals aged ≥ 40 years who underwent health examinations in 2009 (N = 6,883,494), the hazard of dementia was evaluated according to cholesterol levels. During a median 8.33 years, 263,185 dementia cases were detected. In statin non-users with or without diabetes, the hazards of all-cause dementia were highest for those in the lowest quartile or quintile of low-density lipoprotein-cholesterol (LDL-C) level, showing an inverted J-shaped relationship. Among statin users with or without diabetes, an advance in LDL-C group was assoc","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T00:36:47.485Z","creation":"2025-04-04T00:36:47.485Z"},"accession":"S-EPMC9653412","cross_references":{"pubmed":["36371594"],"doi":["10.1038/s41598-022-24153-1"]}}