biostudies-literatureUnknown12(1)Lee YBWe explored the association between cholesterol levels and dementia risk according to the presence of diabetes and statin use. In this population-based longitudinal cohort study, the Korean National Health Insurance Service datasets (2002-2017) were used. Among individuals aged ≥ 40 years who underwent health examinations in 2009 (N = 6,883,494), the hazard of dementia was evaluated according to cholesterol levels. During a median 8.33 years, 263,185 dementia cases were detected. In statin non-users with or without diabetes, the hazards of all-cause dementia were highest for those in the lowest quartile or quintile of low-density lipoprotein-cholesterol (LDL-C) level, showing an inverted J-shaped relationship. Among statin users with or without diabetes, an advance in LDL-C group was assocScientific reports19383https://www.ebi.ac.uk/biostudies/studies/S-EPMC9653412biostudies-literatureAssociation between cholesterol levels and dementia risk according to the presence of diabetes and statin use: a nationwide cohort study.PMC9653412Lee YBKim BHan KPark JKim GKim MYHur KYKim JHJin SMfalseAssociation between cholesterol levels and dementia risk according to the presence of diabetes and statin use: a nationwide cohort study.We explored the association between cholesterol levels and dementia risk according to the presence of diabetes and statin use. In this population-based longitudinal cohort study, the Korean National Health Insurance Service datasets (2002-2017) were used. Among individuals aged ≥ 40 years who underwent health examinations in 2009 (N = 6,883,494), the hazard of dementia was evaluated according to cholesterol levels. During a median 8.33 years, 263,185 dementia cases were detected. In statin non-users with or without diabetes, the hazards of all-cause dementia were highest for those in the lowest quartile or quintile of low-density lipoprotein-cholesterol (LDL-C) level, showing an inverted J-shaped relationship. Among statin users with or without diabetes, an advance in LDL-C group was assoc2022-01-01T00:00:00Z2022 Nov2025-04-04T00:36:47.485Z2025-04-04T00:36:47.485ZS-EPMC96534123637159410.1038/s41598-022-24153-1