{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xiang H"],"funding":["Jiaxing Public Welfare Research Project","National Natural Science Foundation of China","Zhejiang Provincial Natural Science Foundation"],"pagination":["7499"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9653583"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(21)"],"pubmed_abstract":["Hydrogen sulfide (H<sub>2</sub>S) as small molecular signal messenger plays key functions in numerous biological processes. The imaging detection of intracellular hydrogen sulfide is of great significance. In this work, a ratiometric fluorescent probe <b>BH</b> based on an asymmetric BODIPY dye for detection of H<sub>2</sub>S was designed and synthesized. After the interaction with hydrogen sulfide, probe display colorimetric and ratiometric fluorescence response, with its maximum emission fluorescence wavelength red-shifted from 542 nm to 594 nm, which is attributed to the sequential nucleophilic reaction of H<sub>2</sub>S leading to enhanced molecular conjugation after ring formation of the BODIPY skeleton. A special response mechanism has been fully investigated by NMR titration and MS,"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["A New Ratiometric Fluorescent Probe Based on BODIPY for Highly Selective Detection of Hydrogen Sulfide."],"pmcid":["PMC9653583"],"funding_grant_id":["LY20B060009","2021AY10070","22071082","21606102"],"pubmed_authors":["Li Y","Ye T","Xiang H","Lin Y","Liu D","Zhou H","Wang J","Li L"],"additional_accession":[]},"is_claimable":false,"name":"A New Ratiometric Fluorescent Probe Based on BODIPY for Highly Selective Detection of Hydrogen Sulfide.","description":"Hydrogen sulfide (H<sub>2</sub>S) as small molecular signal messenger plays key functions in numerous biological processes. The imaging detection of intracellular hydrogen sulfide is of great significance. In this work, a ratiometric fluorescent probe <b>BH</b> based on an asymmetric BODIPY dye for detection of H<sub>2</sub>S was designed and synthesized. After the interaction with hydrogen sulfide, probe display colorimetric and ratiometric fluorescence response, with its maximum emission fluorescence wavelength red-shifted from 542 nm to 594 nm, which is attributed to the sequential nucleophilic reaction of H<sub>2</sub>S leading to enhanced molecular conjugation after ring formation of the BODIPY skeleton. A special response mechanism has been fully investigated by NMR titration and MS,","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-25T23:23:23.731Z","creation":"2025-04-06T09:22:32.159Z"},"accession":"S-EPMC9653583","cross_references":{"pubmed":["36364325"],"doi":["10.3390/molecules27217499"]}}