{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jiang M"],"funding":["Marine Biotechnology Economic Integration Service Platform from Fujian Association for Science and Technology","National Natural Science Foundation of Fujian Province, China","National Natural Science Foundation of China","National Natural Science Foundation of Fujian Province","Xiamen Ocean and Fishery Development Special Fund Project","Xiamen Science and Technology Planning Project"],"pagination":["13316"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9653689"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(21)"],"pubmed_abstract":["The abuse of antibiotics leads to the increase of bacterial resistance, which seriously threatens human health. Therefore, there is an urgent need to find effective alternatives to antibiotics, and antimicrobial peptides (AMPs) are the most promising antibacterial agents and have received extensive attention. In this study, a novel potential AMP was identified from the marine invertebrate <i>Scylla paramamosain</i> and named Spampcin. After bioinformatics analysis and AMP database prediction, four truncated peptides (Spa31, Spa22, Spa20 and Spa14) derived from Spampcin were screened, all of which showed potent antimicrobial activity with different antibacterial spectrum. Among them, Spampcin<sub>56-86</sub> (Spa31 for short) exhibited strong bactericidal activity against a variety of clini"],"journal":["International journal of molecular sciences"],"pubmed_title":["A Novel Antimicrobial Peptide Spampcin<sub>56-86</sub> from <i>Scylla paramamosain</i> Exerting Rapid Bactericidal and Anti-Biofilm Activity In Vitro and Anti-Infection In Vivo."],"pmcid":["PMC9653689"],"funding_grant_id":["#20CZP011HJ06","U1805233","#2021J05008","#U1805233","2021J05008","20CZP011HJ06","#3502Z20203012","3502Z20203012"],"pubmed_authors":["Zhang J","Chen F","Jiang M","Chen R","Wang KJ"],"additional_accession":[]},"is_claimable":false,"name":"A Novel Antimicrobial Peptide Spampcin<sub>56-86</sub> from <i>Scylla paramamosain</i> Exerting Rapid Bactericidal and Anti-Biofilm Activity In Vitro and Anti-Infection In Vivo.","description":"The abuse of antibiotics leads to the increase of bacterial resistance, which seriously threatens human health. Therefore, there is an urgent need to find effective alternatives to antibiotics, and antimicrobial peptides (AMPs) are the most promising antibacterial agents and have received extensive attention. In this study, a novel potential AMP was identified from the marine invertebrate <i>Scylla paramamosain</i> and named Spampcin. After bioinformatics analysis and AMP database prediction, four truncated peptides (Spa31, Spa22, Spa20 and Spa14) derived from Spampcin were screened, all of which showed potent antimicrobial activity with different antibacterial spectrum. Among them, Spampcin<sub>56-86</sub> (Spa31 for short) exhibited strong bactericidal activity against a variety of clini","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T00:36:52.099Z","creation":"2025-04-04T00:36:52.099Z"},"accession":"S-EPMC9653689","cross_references":{"pubmed":["36362111"],"doi":["10.3390/ijms232113316"]}}