{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Banfi C"],"funding":["Dept of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano","the Italian Ministry of Health, Roma, Italy"],"pagination":["13487"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9654901"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(21)"],"pubmed_abstract":["The human long pentraxin PTX3 has complex regulatory roles at the crossroad of innate immunity, inflammation, and tissue repair. PTX3 can be produced by various cell types, including vascular endothelial cells (ECs), in response to pro-inflammatory cytokines or bacterial molecules. PTX3 has also been involved in the regulation of cardiovascular biology, even if ambiguous results have been so far provided in both preclinical and clinical research. In this study, we compared the proteomic profiles of human ECs (human umbilical vein ECs, HUVECs), focusing on differentially expressed proteins between the control and PTX3-silenced ECs. We identified 19 proteins that were more abundant in the proteome of control ECs and 23 proteins that were more expressed in PTX3-silenced cells. Among the latte"],"journal":["International journal of molecular sciences"],"pubmed_title":["The Effects of Silencing PTX3 on the Proteome of Human Endothelial Cells."],"pmcid":["PMC9654901"],"funding_grant_id":["G49C20001270001","Ricerca Corrente RC 2021"],"pubmed_authors":["Vicentini LM","Cattaneo MG","Banfi C","Brioschi M"],"additional_accession":[]},"is_claimable":false,"name":"The Effects of Silencing PTX3 on the Proteome of Human Endothelial Cells.","description":"The human long pentraxin PTX3 has complex regulatory roles at the crossroad of innate immunity, inflammation, and tissue repair. PTX3 can be produced by various cell types, including vascular endothelial cells (ECs), in response to pro-inflammatory cytokines or bacterial molecules. PTX3 has also been involved in the regulation of cardiovascular biology, even if ambiguous results have been so far provided in both preclinical and clinical research. In this study, we compared the proteomic profiles of human ECs (human umbilical vein ECs, HUVECs), focusing on differentially expressed proteins between the control and PTX3-silenced ECs. We identified 19 proteins that were more abundant in the proteome of control ECs and 23 proteins that were more expressed in PTX3-silenced cells. Among the latte","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-04-08T11:43:21.799Z","creation":"2025-04-06T01:49:45.979Z"},"accession":"S-EPMC9654901","cross_references":{"pubmed":["36362273"],"doi":["10.3390/ijms232113487"]}}