biostudies-literatureCrawford COffice of Dietary SupplementsConsortium for Health and Military Performance, Uniformed Services University4604https://www.ebi.ac.uk/biostudies/studies/S-EPMC9655067biostudies-literatureUnknown14(21)Immune health products represent approximately 10% of all US dietary supplement sales. Claims made on products to support or boost the immune system are attractive to the otherwise healthy consumer who may or may not be experiencing certain life stressors. The purpose of this systematic review is to critically evaluate the purported benefits and/or potential harms of select dietary supplement ingredients frequently listed on the labels of products having immune health or related market claims. With a focus on resilience, research questions were related to whether dietary supplement ingredients are efficacious in preserving and protecting immune health in healthy individuals; and when faced with a stressor, whether taking a supplement prophylactically can assist in maintaining health and reNutrientsSelect Dietary Supplement Ingredients for Preserving and Protecting the Immune System in Healthy Individuals: A Systematic Review.PMC9655067HU0001-21-1-0004HU0001-18-2-0099Deuster PABrown LLCostello RBCrawford CfalseSelect Dietary Supplement Ingredients for Preserving and Protecting the Immune System in Healthy Individuals: A Systematic Review.Immune health products represent approximately 10% of all US dietary supplement sales. Claims made on products to support or boost the immune system are attractive to the otherwise healthy consumer who may or may not be experiencing certain life stressors. The purpose of this systematic review is to critically evaluate the purported benefits and/or potential harms of select dietary supplement ingredients frequently listed on the labels of products having immune health or related market claims. With a focus on resilience, research questions were related to whether dietary supplement ingredients are efficacious in preserving and protecting immune health in healthy individuals; and when faced with a stressor, whether taking a supplement prophylactically can assist in maintaining health and re2022-01-01T00:00:00Z2022 Nov2025-04-25T23:42:34.288Z2025-04-06T09:25:13.981ZS-EPMC96550673636486510.3390/nu14214604