biostudies-literatureLiu XNational Key R&amp;D Program of ChinaZhejiang Research Center of Cardiovascular Diagnosis and Treatment TechnologyZhejiang Province Science and Technology Department Key R&amp;D ProgramThe National Natural Science Foundation of China6502https://www.ebi.ac.uk/biostudies/studies/S-EPMC9655232biostudies-literatureUnknown11(21)Evidence for transcatheter aortic valve implantation (TAVI) is scarce among patients with non-calcific aortic stenosis, and it is not known whether aortic valve calcification is associated with new cerebral ischemic lesions (CILs) that are detected by diffusion-weighted magnetic resonance imaging. So, our study enrolled 328 patients who underwent transfemoral TAVI using a self-expanding valve between December 2016 and June 2021 from the TORCH registry (NCT02803294). A total of 34 patients were finally confirmed as non-calcific AS and the remaining 294 patients were included in the calcific AS group. Incidence of new CILs (70.6% vs. 85.7%, <i>p</i> = 0.022), number of lesions (2.0 vs. 3.0, <i>p</i> = 0.010), and lesions volume (105.0 mm³ vs. 200.0 mm³, <i>p</i> = 0.047) was significantly lower in the non-calcific AS group. However, the maximum and average lesion volumes were comparable between two groups. Non-calcific AS was associated with lower risk for developing new CILs by univariate logistic regression analysis [Odds ratio (OR): 0.040, 95% confident interval (CI): 0.18-0.90, <i>p</i> = 0.026] and multivariate analysis (OR: 0.031, 95% CI: 0.13-0.76, <i>p</i> = 0.010). In summary, non-calcific AS patients had a lower risk of developing new cerebral ischemic infarction after TAVI compared to calcific AS patients. However, new ischemic lesions were still found in over 70% of patients.Journal of clinical medicineCerebral Ischemic Lesions after Transcatheter Aortic Valve Implantation in Patients with Non-Calcific Aortic Stenosis.PMC965523281770252JBZX-202001818702922022C03063815702332019YFA01104002018C030842021C03097Chen JGuo YLiu QZhu GWei YWang JYidilisi ALiu XHe YFan JQi XZhou DZhu QDai HfalseCerebral Ischemic Lesions after Transcatheter Aortic Valve Implantation in Patients with Non-Calcific Aortic Stenosis.Evidence for transcatheter aortic valve implantation (TAVI) is scarce among patients with non-calcific aortic stenosis, and it is not known whether aortic valve calcification is associated with new cerebral ischemic lesions (CILs) that are detected by diffusion-weighted magnetic resonance imaging. So, our study enrolled 328 patients who underwent transfemoral TAVI using a self-expanding valve between December 2016 and June 2021 from the TORCH registry (NCT02803294). A total of 34 patients were finally confirmed as non-calcific AS and the remaining 294 patients were included in the calcific AS group. Incidence of new CILs (70.6% vs. 85.7%, <i>p</i> = 0.022), number of lesions (2.0 vs. 3.0, <i>p</i> = 0.010), and lesions volume (105.0 mm³ vs. 200.0 mm³, <i>p</i> = 0.047) was significantly lower in the non-calcific AS group. However, the maximum and average lesion volumes were comparable between two groups. Non-calcific AS was associated with lower risk for developing new CILs by univariate logistic regression analysis [Odds ratio (OR): 0.040, 95% confident interval (CI): 0.18-0.90, <i>p</i> = 0.026] and multivariate analysis (OR: 0.031, 95% CI: 0.13-0.76, <i>p</i> = 0.010). In summary, non-calcific AS patients had a lower risk of developing new cerebral ischemic infarction after TAVI compared to calcific AS patients. However, new ischemic lesions were still found in over 70% of patients.2022-01-01T00:00:00Z2022 Nov2025-04-25T23:27:04.965Z2025-04-06T09:21:16.19ZS-EPMC96552323636273010.3390/jcm11216502