{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(21)"],"submitter":["Perri MR"],"pubmed_abstract":["Different phytochemical compounds have been demonstrated to modulate the JAK/STAT signaling pathway. Here, three <i>Cachrys</i> species from Southern Italy were investigated for both the phytochemical profile and the potential anti-inflammatory properties. The aerial parts were extracted with methanol through Naviglio Extractor<sup>®</sup>, an innovative solid-liquid extraction technique that allows to obtain high quality extracts by working with gradient pressure. Extracts were analyzed with GC-MS and standardized in furanocoumarin content, resulting rich in xanthotoxin, bergapten and isopimpinellin. Given the known ability of bergapten to inhibit the JAK/STAT signaling pathway by decreasing the levels of pro-inflammatory cytokines (TNF-α, IL-6) and inflammatory mediators (NO) in RAW 264."],"journal":["Plants (Basel, Switzerland)"],"pagination":["2913"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9655331"],"repository":["biostudies-literature"],"pubmed_title":["<i>Cachrys</i> spp. from Southern Italy: Phytochemical Characterization and JAK/STAT Signaling Pathway Inhibition."],"pmcid":["PMC9655331"],"pubmed_authors":["Perri MR","Aquaro S","Statti G","Cavaliere F","Pellegrino M","Marrelli M","Conforti F","Uzunov D","Lupia C"],"additional_accession":[]},"is_claimable":false,"name":"<i>Cachrys</i> spp. from Southern Italy: Phytochemical Characterization and JAK/STAT Signaling Pathway Inhibition.","description":"Different phytochemical compounds have been demonstrated to modulate the JAK/STAT signaling pathway. Here, three <i>Cachrys</i> species from Southern Italy were investigated for both the phytochemical profile and the potential anti-inflammatory properties. The aerial parts were extracted with methanol through Naviglio Extractor<sup>®</sup>, an innovative solid-liquid extraction technique that allows to obtain high quality extracts by working with gradient pressure. Extracts were analyzed with GC-MS and standardized in furanocoumarin content, resulting rich in xanthotoxin, bergapten and isopimpinellin. Given the known ability of bergapten to inhibit the JAK/STAT signaling pathway by decreasing the levels of pro-inflammatory cytokines (TNF-α, IL-6) and inflammatory mediators (NO) in RAW 264.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-22T12:39:47.979Z","creation":"2025-04-06T00:19:44.181Z"},"accession":"S-EPMC9655331","cross_references":{"pubmed":["36365365"],"doi":["10.3390/plants11212913"]}}