{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Volkova MS"],"funding":["Russian Science Foundation"],"pagination":["7462"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9655341"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(21)"],"pubmed_abstract":["2,3-Dihydroindoles are promising agents for the synthesis of new compounds with neuroprotective and antioxidant properties. Usually, these compounds are obtained by direct reduction of the corresponding indoles containing acceptor groups in the indole ring for its activation. In this work, we propose a synthetic strategy to obtain new 2,3-dihydroindole derivatives from the corresponding polyfunctional 2-oxindoles. Three methods were proposed for reduction of functional groups in the 2-oxindole and 2-chloroindole molecules using various boron hydrides. The possibility of chemoselective reduction of the nitrile group in the presence of an amide was shown. The proposed synthetic strategy can be used, for example, for the synthesis of new analogs of the endogenous hormone melatonin and other c"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Synthesis of New 2,3-Dihydroindole Derivatives and Evaluation of Their Melatonin Receptor Binding Affinity."],"pmcid":["PMC9655341"],"funding_grant_id":["22-13-00228"],"pubmed_authors":["Bezsonova EN","Lozinskaya NA","Efremov AM","Maksutova AI","Salykina MA","Sosonyuk SE","Volkova MS","Shevtsova EF","Tsymliakov MD"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of New 2,3-Dihydroindole Derivatives and Evaluation of Their Melatonin Receptor Binding Affinity.","description":"2,3-Dihydroindoles are promising agents for the synthesis of new compounds with neuroprotective and antioxidant properties. Usually, these compounds are obtained by direct reduction of the corresponding indoles containing acceptor groups in the indole ring for its activation. In this work, we propose a synthetic strategy to obtain new 2,3-dihydroindole derivatives from the corresponding polyfunctional 2-oxindoles. Three methods were proposed for reduction of functional groups in the 2-oxindole and 2-chloroindole molecules using various boron hydrides. The possibility of chemoselective reduction of the nitrile group in the presence of an amide was shown. The proposed synthetic strategy can be used, for example, for the synthesis of new analogs of the endogenous hormone melatonin and other c","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-22T12:31:34.531Z","creation":"2025-04-06T00:22:00.901Z"},"accession":"S-EPMC9655341","cross_references":{"pubmed":["36364290"],"doi":["10.3390/molecules27217462"]}}