biostudies-literatureUnknown11(21)Martinino AHepatocellular carcinoma ranks fifth amongst the most common malignancies and is the third most common cause of cancer-related death globally. Artificial Intelligence is a rapidly growing field of interest. Following the PRISMA reporting guidelines, we conducted a systematic review to retrieve articles reporting the application of AI in HCC detection and characterization. A total of 27 articles were included and analyzed with our composite score for the evaluation of the quality of the publications. The contingency table reported a statistically significant constant improvement over the years of the total quality score (<i>p</i> = 0.004). Different AI methods have been adopted in the included articles correlated with 19 articles studying CT (41.30%), 20 studying US (43.47%), and 7 studyingJournal of clinical medicine6368https://www.ebi.ac.uk/biostudies/studies/S-EPMC9655417biostudies-literatureArtificial Intelligence in the Diagnosis of Hepatocellular Carcinoma: A Systematic Review.PMC9655417Annunziata SAloulou MKirchgesner TPSinghal SPatel TGiovinazzo FChatterjee SScarano Pereira JPAgnes STreglia GMartinino AfalseArtificial Intelligence in the Diagnosis of Hepatocellular Carcinoma: A Systematic Review.Hepatocellular carcinoma ranks fifth amongst the most common malignancies and is the third most common cause of cancer-related death globally. Artificial Intelligence is a rapidly growing field of interest. Following the PRISMA reporting guidelines, we conducted a systematic review to retrieve articles reporting the application of AI in HCC detection and characterization. A total of 27 articles were included and analyzed with our composite score for the evaluation of the quality of the publications. The contingency table reported a statistically significant constant improvement over the years of the total quality score (<i>p</i> = 0.004). Different AI methods have been adopted in the included articles correlated with 19 articles studying CT (41.30%), 20 studying US (43.47%), and 7 studying2022-01-01T00:00:00Z2022 Oct2025-04-25T23:41:16.614Z2025-04-06T09:25:56.597ZS-EPMC96554173636259610.3390/jcm11216368