{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gao M"],"funding":["National Natural Science Foundation of China","Project of Innovation-driven Plan in Central South University","National Key Research and Development Program of China","Science and Technology Innovation Program of Hunan Province"],"pagination":["6486"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9655533"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(21)"],"pubmed_abstract":["<h4>Backgrounds</h4>Angiotensin receptor blockers (ARB), angiotensin converting enzyme inhibitor (ACEI), calcium channel blocker (CCB) and thiazide diuretics (TD) are common antihypertensive drugs for diabetes patients with hypertension. The purpose of this study was to compare the cardiovascular risks of these drugs in patients with isolated systolic hypertension (ISH) and type 2 diabetes mellitus (T2DM).<h4>Methods</h4>We used Action to Control Cardiovascular Risk in Diabetes trial data to explore the relationship between antihypertensive drugs and cardiovascular risks in ISH with T2DM patients by performing propensity score matching, Kaplan-Meier survival analyses and Cox proportional regression.<h4>Results</h4>The cumulative incidence rates of primary outcomes (PO, including cardiovasc"],"journal":["Journal of clinical medicine"],"pubmed_title":["The Impact of Different Antihypertensive Drugs on Cardiovascular Risk in Isolated Systolic Hypertension with Type 2 Diabetes Patients."],"pmcid":["PMC9655533"],"funding_grant_id":["2020YFC2008002","2020CX017","2020RC4006 and 2021RC2014","81822004"],"pubmed_authors":["Gao M","Xie H","Lin W","Luo Y","Ma T","Bai Y","Cheng X"],"additional_accession":[]},"is_claimable":false,"name":"The Impact of Different Antihypertensive Drugs on Cardiovascular Risk in Isolated Systolic Hypertension with Type 2 Diabetes Patients.","description":"<h4>Backgrounds</h4>Angiotensin receptor blockers (ARB), angiotensin converting enzyme inhibitor (ACEI), calcium channel blocker (CCB) and thiazide diuretics (TD) are common antihypertensive drugs for diabetes patients with hypertension. The purpose of this study was to compare the cardiovascular risks of these drugs in patients with isolated systolic hypertension (ISH) and type 2 diabetes mellitus (T2DM).<h4>Methods</h4>We used Action to Control Cardiovascular Risk in Diabetes trial data to explore the relationship between antihypertensive drugs and cardiovascular risks in ISH with T2DM patients by performing propensity score matching, Kaplan-Meier survival analyses and Cox proportional regression.<h4>Results</h4>The cumulative incidence rates of primary outcomes (PO, including cardiovasc","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-25T23:34:39.282Z","creation":"2025-04-06T09:26:26.901Z"},"accession":"S-EPMC9655533","cross_references":{"pubmed":["36362714"],"doi":["10.3390/jcm11216486"]}}