{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jiang M"],"funding":["Outstanding Young and Middle-aged Backbone Talents Project from Jilin Province Department of Finance","Natural Science Foundation Project from Jilin Provincial Department of Science and Technology","Bethune Planned Research project from Jilin University","Natural Science Foundation Project from Department of Science & Technology of Liaoning Province"],"pagination":["3473"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9655729"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(21)"],"pubmed_abstract":["M1 phenotype macrophages have anticancer characteristics, whereas M2 phenotype macrophages promote tumor growth and metastasis. A higher M1/M2 ratio, therefore, has a beneficial effect on the tumor immune microenvironment, thereby inhibiting tumor growth. The natural alkaloid curcumin is found to have anticancer properties. However, the mechanism remains unclear. In this study, a cell co-culture system and M2 macrophage model were used to evaluate the effects of curcumin on tumor-associated macrophage (TAM) phenotypes. Our results demonstrate that curcumin reprogrammed the M2 macrophages by reducing the level of anti-inflammatory cytokines (TGF-β, Arg-1, and IL-10) and an M2 surface marker (CD206) induced by Cal27 cells or IL-4, as well as upregulating proinflammatory cytokines (TNF-α, iNO"],"journal":["Cells"],"pubmed_title":["Curcumin Reprograms TAMs from a Protumor Phenotype towards an Antitumor Phenotype via Inhibiting MAO-A/STAT6 Pathway."],"pmcid":["PMC9655729"],"funding_grant_id":["20200201329JC","2021-MS-175","JCSZ2019378-14","2018B27"],"pubmed_authors":["Huang W","Qi Y","Lin Y","Li B","Jiang M"],"additional_accession":[]},"is_claimable":false,"name":"Curcumin Reprograms TAMs from a Protumor Phenotype towards an Antitumor Phenotype via Inhibiting MAO-A/STAT6 Pathway.","description":"M1 phenotype macrophages have anticancer characteristics, whereas M2 phenotype macrophages promote tumor growth and metastasis. A higher M1/M2 ratio, therefore, has a beneficial effect on the tumor immune microenvironment, thereby inhibiting tumor growth. The natural alkaloid curcumin is found to have anticancer properties. However, the mechanism remains unclear. In this study, a cell co-culture system and M2 macrophage model were used to evaluate the effects of curcumin on tumor-associated macrophage (TAM) phenotypes. Our results demonstrate that curcumin reprogrammed the M2 macrophages by reducing the level of anti-inflammatory cytokines (TGF-β, Arg-1, and IL-10) and an M2 surface marker (CD206) induced by Cal27 cells or IL-4, as well as upregulating proinflammatory cytokines (TNF-α, iNO","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-19T06:38:18.738Z","creation":"2025-04-19T06:38:18.738Z"},"accession":"S-EPMC9655729","cross_references":{"pubmed":["36359867"],"doi":["10.3390/cells11213473"]}}