biostudies-literatureQueiros CFundação para a Ciência e Tecnologia7219https://www.ebi.ac.uk/biostudies/studies/S-EPMC9656197biostudies-literatureUnknown27(21)The search for accurate and sensitive methods to detect chemical substances, namely cations and anions, is urgent and widely sought due to the enormous impact that some of these chemical species have on human health and on the environment. Here, we present a new platform for the efficient sensing of Cu²⁺ and Li⁺ cations. For this purpose, two novel photoactive diketopyrrolopyrrole-rhodamine conjugates were synthesized through the condensation of a diketopyrrolopyrrole dicarbaldehyde with rhodamine B hydrazide. The resulting chemosensors <b>1</b> and <b>2</b>, bearing one or two rhodamine hydrazide moieties, respectively, were characterized by ¹H and ¹³C NMR and high-resolution mass spectrometry, and their photophysical and ion-responsive behaviouMolecules (Basel, Switzerland)Synthesis of Novel Diketopyrrolopyrrole-Rhodamine Conjugates and Their Ability for Sensing Cu²⁺ and Li.PMC9656197PTDC/QUI-QIN/28142/2017EXPL/QUI-OUT/1554/2021UIDB/50006/2020 | UIDP/50006/2020PTDC/QUI-QOR/29426/2017Leite ASilva AMGMartins FQueiros CTome ACAlmodovar VASfalseSynthesis of Novel Diketopyrrolopyrrole-Rhodamine Conjugates and Their Ability for Sensing Cu²⁺ and Li.The search for accurate and sensitive methods to detect chemical substances, namely cations and anions, is urgent and widely sought due to the enormous impact that some of these chemical species have on human health and on the environment. Here, we present a new platform for the efficient sensing of Cu²⁺ and Li⁺ cations. For this purpose, two novel photoactive diketopyrrolopyrrole-rhodamine conjugates were synthesized through the condensation of a diketopyrrolopyrrole dicarbaldehyde with rhodamine B hydrazide. The resulting chemosensors <b>1</b> and <b>2</b>, bearing one or two rhodamine hydrazide moieties, respectively, were characterized by ¹H and ¹³C NMR and high-resolution mass spectrometry, and their photophysical and ion-responsive behaviou2022-01-01T00:00:00Z2022 Oct2025-04-25T23:41:01.917Z2025-04-06T09:23:14.553ZS-EPMC96561973636404210.3390/molecules27217219