{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(21)"],"submitter":["Kim TH"],"pubmed_abstract":["<i>Ligularia fischeri</i> Turcz leaves are widely consumed and have multiple health benefits. We aimed to evaluate the differences in the phytochemical composition and biological properties of the root and leaf extracts from <i>L. fischeri</i>. The root extract exhibited higher antioxidant capacity and total flavonoid levels than the leaf extract. GC/MS analysis revealed the presence of various volatiles, diterpenoids, sesquiterpenes, and other non-polar compounds. Moreover, these extracts enhanced cellular antioxidant defense by reducing the level of reactive oxygen species and upregulating the expression of catalase and heme oxygenase-1 in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The root and leaf extracts also exerted anti-inflammatory effects by suppressing nitric oxide pro"],"journal":["Plants (Basel, Switzerland)"],"pagination":["3005"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9656575"],"repository":["biostudies-literature"],"pubmed_title":["Phytochemical Composition and Antioxidant and Anti-Inflammatory Activities of <i>Ligularia fischeri</i> Turcz: A Comparison between Leaf and Root Extracts."],"pmcid":["PMC9656575"],"pubmed_authors":["Kim TH","Jeong WS","Truong VL"],"additional_accession":[]},"is_claimable":false,"name":"Phytochemical Composition and Antioxidant and Anti-Inflammatory Activities of <i>Ligularia fischeri</i> Turcz: A Comparison between Leaf and Root Extracts.","description":"<i>Ligularia fischeri</i> Turcz leaves are widely consumed and have multiple health benefits. We aimed to evaluate the differences in the phytochemical composition and biological properties of the root and leaf extracts from <i>L. fischeri</i>. The root extract exhibited higher antioxidant capacity and total flavonoid levels than the leaf extract. GC/MS analysis revealed the presence of various volatiles, diterpenoids, sesquiterpenes, and other non-polar compounds. Moreover, these extracts enhanced cellular antioxidant defense by reducing the level of reactive oxygen species and upregulating the expression of catalase and heme oxygenase-1 in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The root and leaf extracts also exerted anti-inflammatory effects by suppressing nitric oxide pro","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-22T12:29:21.361Z","creation":"2025-04-06T00:21:38.677Z"},"accession":"S-EPMC9656575","cross_references":{"pubmed":["36365457"],"doi":["10.3390/plants11213005"]}}