biostudies-literatureUnknown11(21)Kim TH<i>Ligularia fischeri</i> Turcz leaves are widely consumed and have multiple health benefits. We aimed to evaluate the differences in the phytochemical composition and biological properties of the root and leaf extracts from <i>L. fischeri</i>. The root extract exhibited higher antioxidant capacity and total flavonoid levels than the leaf extract. GC/MS analysis revealed the presence of various volatiles, diterpenoids, sesquiterpenes, and other non-polar compounds. Moreover, these extracts enhanced cellular antioxidant defense by reducing the level of reactive oxygen species and upregulating the expression of catalase and heme oxygenase-1 in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The root and leaf extracts also exerted anti-inflammatory effects by suppressing nitric oxide proPlants (Basel, Switzerland)3005https://www.ebi.ac.uk/biostudies/studies/S-EPMC9656575biostudies-literaturePhytochemical Composition and Antioxidant and Anti-Inflammatory Activities of <i>Ligularia fischeri</i> Turcz: A Comparison between Leaf and Root Extracts.PMC9656575Kim THJeong WSTruong VLfalsePhytochemical Composition and Antioxidant and Anti-Inflammatory Activities of <i>Ligularia fischeri</i> Turcz: A Comparison between Leaf and Root Extracts.<i>Ligularia fischeri</i> Turcz leaves are widely consumed and have multiple health benefits. We aimed to evaluate the differences in the phytochemical composition and biological properties of the root and leaf extracts from <i>L. fischeri</i>. The root extract exhibited higher antioxidant capacity and total flavonoid levels than the leaf extract. GC/MS analysis revealed the presence of various volatiles, diterpenoids, sesquiterpenes, and other non-polar compounds. Moreover, these extracts enhanced cellular antioxidant defense by reducing the level of reactive oxygen species and upregulating the expression of catalase and heme oxygenase-1 in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The root and leaf extracts also exerted anti-inflammatory effects by suppressing nitric oxide pro2022-01-01T00:00:00Z2022 Nov2025-04-22T12:29:21.361Z2025-04-06T00:21:38.677ZS-EPMC96565753636545710.3390/plants11213005