{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Samakovli D"],"funding":["General Secretariat for Research and Technology","Hellenic Foundation for Research and Innovation"],"pagination":["3341"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9656807"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(21)"],"pubmed_abstract":["The activation of BRASSINOSTEROID INSENSITIVE1 (BRI1) and its association with the BRI1 ASSOCIATED RECEPTOR KINASE1 (BAK1) are key steps for the initiation of the BR signaling cascade mediating hypocotyl elongation. Heat shock protein 90 (HSP90) is crucial in the regulation of signaling processes and the activation of hormonal receptors. We report that HSP90 is required for the maintenance of the BRI1 receptor at the plasma membrane (PM) and its association with the BAK1 co-receptor during BL-ligand stimulation. HSP90 mediates BR perception and signal transduction through physical interactions with BRI1 and BAK1, while chaperone depletion resulted in lower levels of BRI1 and BAK1 receptors at the PM and affected the spatial partitioning and organization of BRI1/BAK1 heterocomplexes at the "],"journal":["Cells"],"pubmed_title":["BRI1 and BAK1 Canonical Distribution in Plasma Membrane Is HSP90 Dependent."],"pmcid":["PMC9656807"],"funding_grant_id":["GSRT- BELiCy/1200","HFRI-2020-02746"],"pubmed_authors":["Hatzopoulos P","Samakovli D","Roka L","Plitsi PK","Stravopodis DJ","Milioni D","Haralampidis K","Drakakaki G"],"additional_accession":[]},"is_claimable":false,"name":"BRI1 and BAK1 Canonical Distribution in Plasma Membrane Is HSP90 Dependent.","description":"The activation of BRASSINOSTEROID INSENSITIVE1 (BRI1) and its association with the BRI1 ASSOCIATED RECEPTOR KINASE1 (BAK1) are key steps for the initiation of the BR signaling cascade mediating hypocotyl elongation. Heat shock protein 90 (HSP90) is crucial in the regulation of signaling processes and the activation of hormonal receptors. We report that HSP90 is required for the maintenance of the BRI1 receptor at the plasma membrane (PM) and its association with the BAK1 co-receptor during BL-ligand stimulation. HSP90 mediates BR perception and signal transduction through physical interactions with BRI1 and BAK1, while chaperone depletion resulted in lower levels of BRI1 and BAK1 receptors at the PM and affected the spatial partitioning and organization of BRI1/BAK1 heterocomplexes at the ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-25T23:29:34.489Z","creation":"2025-04-06T09:21:44.938Z"},"accession":"S-EPMC9656807","cross_references":{"pubmed":["36359737"],"doi":["10.3390/cells11213341"]}}