{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song CY"],"funding":["Ministry of Science and Technology","China Medical University Hospital","China Medical University"],"pagination":["3470"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9656973"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(21)"],"pubmed_abstract":["New treatments for chondrosarcoma are extremely important. Chondrosarcoma is a primary malignant bone tumor with a very unfavorable prognosis. High-grade chondrosarcoma has a high potential to metastasize to any organ in the body. Platelet-derived growth factor (PDGF) is a potent angiogenic factor that promotes tumor angiogenesis and metastasis. The adipocytokine visfatin promotes metastatic potential of chondrosarcoma; however, the role of visfatin in angiogenesis in human chondrosarcoma is unclear. We report that the levels of PDGF-C expression were positively correlated with tumor stages, significantly higher than the levels of expression in normal cartilage. Visfatin increased PDGF-C expression and endothelial progenitor cell (EPC) angiogenesis through the PI3K/Akt/mTOR signaling pathw"],"journal":["Cells"],"pubmed_title":["Visfatin-Induced Inhibition of miR-1264 Facilitates PDGF-C Synthesis in Chondrosarcoma Cells and Enhances Endothelial Progenitor Cell Angiogenesis."],"pmcid":["PMC9656973"],"funding_grant_id":["DMR-111-108","CMU110-ASIA-02","DMR-111-229","DMR-111-235","MOST 108-2314-B-039-034 -MY3"],"pubmed_authors":["Huang YW","Wang SW","Tsai CH","Tang CH","Fong YC","Chen WC","Yang SY","Song CY","Chang SL","Lin CY"],"additional_accession":[]},"is_claimable":false,"name":"Visfatin-Induced Inhibition of miR-1264 Facilitates PDGF-C Synthesis in Chondrosarcoma Cells and Enhances Endothelial Progenitor Cell Angiogenesis.","description":"New treatments for chondrosarcoma are extremely important. Chondrosarcoma is a primary malignant bone tumor with a very unfavorable prognosis. High-grade chondrosarcoma has a high potential to metastasize to any organ in the body. Platelet-derived growth factor (PDGF) is a potent angiogenic factor that promotes tumor angiogenesis and metastasis. The adipocytokine visfatin promotes metastatic potential of chondrosarcoma; however, the role of visfatin in angiogenesis in human chondrosarcoma is unclear. We report that the levels of PDGF-C expression were positively correlated with tumor stages, significantly higher than the levels of expression in normal cartilage. Visfatin increased PDGF-C expression and endothelial progenitor cell (EPC) angiogenesis through the PI3K/Akt/mTOR signaling pathw","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-25T23:36:53.447Z","creation":"2025-02-19T00:31:58.479Z"},"accession":"S-EPMC9656973","cross_references":{"pubmed":["36359873"],"doi":["10.3390/cells11213470"]}}