biostudies-literatureNunez-Sanchez MAFundación Séneca-Murcia Regional Agency for Science and TechnologyInstitute of Health "Carlos III"Miguel Servet Type IInstitute of Health "Carlos III" (ISCIII)13400https://www.ebi.ac.uk/biostudies/studies/S-EPMC9657236biostudies-literatureUnknown23(21)Acute myeloid leukemia (AML) is a cancer of the myeloid blood cells mainly treated with chemotherapy for cancer remission, but this non-selective treatment also induces numerous side effects. Investigations with bioactive compounds from plant-derived foods against cancer have increased in the last years because there is an urgent need to search for new anti-leukemic agents possessing higher efficacy and selectivity for AML cells and fewer negative side effects. In this study, we analyzed the anti-leukemic activity of several phytochemicals that are representative of the major classes of compounds present in cruciferous foods (glucosinolates, isothiocyanates, hydroxycinnamic acids, flavonols, and anthocyanins) in the human acute myeloid leukemia cell line HL-60. Our results revealed that amInternational journal of molecular sciencesAnti-Leukemic Activity of Brassica-Derived Bioactive Compounds in HL-60 Myeloid Leukemia Cells.PMC9657236CP19/0009820855/PI/18FI21/00003PI20/00505Nunez-Sanchez MAGarcia-Ibanez PVerdejo-Sanchez MMartinez-Sanchez MARamos-Molina BRuiz-Alcaraz AJOliva Bolarin AMoreno DAfalseAnti-Leukemic Activity of Brassica-Derived Bioactive Compounds in HL-60 Myeloid Leukemia Cells.Acute myeloid leukemia (AML) is a cancer of the myeloid blood cells mainly treated with chemotherapy for cancer remission, but this non-selective treatment also induces numerous side effects. Investigations with bioactive compounds from plant-derived foods against cancer have increased in the last years because there is an urgent need to search for new anti-leukemic agents possessing higher efficacy and selectivity for AML cells and fewer negative side effects. In this study, we analyzed the anti-leukemic activity of several phytochemicals that are representative of the major classes of compounds present in cruciferous foods (glucosinolates, isothiocyanates, hydroxycinnamic acids, flavonols, and anthocyanins) in the human acute myeloid leukemia cell line HL-60. Our results revealed that am2022-01-01T00:00:00Z2022 Nov2025-04-22T12:33:44.899Z2025-04-06T00:17:49.27ZS-EPMC96572363636220210.3390/ijms232113400