{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yan MX"],"funding":["National Natural Science Foundation of China"],"pagination":["4541"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9657607"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(21)"],"pubmed_abstract":["<b>Background</b>: The purpose of this study was to investigate the relationship between folic acid and iron nutrition during pregnancy and congenital heart disease (CHD) in the offspring. <b>Methods</b>: Conditional logistic regression models and nonlinear mixed-effects models were used to analyze the effects of folic acid and iron nutrition during pregnancy on CHD in offspring. <b>Results</b>: After adjusting for confounders, folic acid or iron supplementation during pregnancy reduced the risk for fetal CHD (<i>OR</i> = 0.60 (0.45, 0.82) or 0.36 (0.27, 0.48)). Similarly, dietary iron intake during pregnancy (≥29 mg/d) was associated with a reduced risk of fetal CHD (<i>OR</i> = 0.64 (0.46, 0.88)). Additionally, compared with women who only supplemented folic acid (<i>OR</i> = 0.59 (0.41,"],"journal":["Nutrients"],"pubmed_title":["The Association of Folic Acid, Iron Nutrition during Pregnancy and Congenital Heart Disease in Northwestern China: A Matched Case-Control Study."],"pmcid":["PMC9657607"],"funding_grant_id":["82103924","81230016","72174167"],"pubmed_authors":["Rong PX","Zhao DD","Qu PF","Duan XY","Yan MX","Zhang R","Zhao Y","Dang SN","Dang YS","Pei LL"],"additional_accession":[]},"is_claimable":false,"name":"The Association of Folic Acid, Iron Nutrition during Pregnancy and Congenital Heart Disease in Northwestern China: A Matched Case-Control Study.","description":"<b>Background</b>: The purpose of this study was to investigate the relationship between folic acid and iron nutrition during pregnancy and congenital heart disease (CHD) in the offspring. <b>Methods</b>: Conditional logistic regression models and nonlinear mixed-effects models were used to analyze the effects of folic acid and iron nutrition during pregnancy on CHD in offspring. <b>Results</b>: After adjusting for confounders, folic acid or iron supplementation during pregnancy reduced the risk for fetal CHD (<i>OR</i> = 0.60 (0.45, 0.82) or 0.36 (0.27, 0.48)). Similarly, dietary iron intake during pregnancy (≥29 mg/d) was associated with a reduced risk of fetal CHD (<i>OR</i> = 0.64 (0.46, 0.88)). Additionally, compared with women who only supplemented folic acid (<i>OR</i> = 0.59 (0.41,","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-26T11:58:43.739Z","creation":"2025-04-06T13:50:00.266Z"},"accession":"S-EPMC9657607","cross_references":{"pubmed":["36364804"],"doi":["10.3390/nu14214541"]}}