biostudies-literatureYan MXNational Natural Science Foundation of China4541https://www.ebi.ac.uk/biostudies/studies/S-EPMC9657607biostudies-literatureUnknown14(21)<b>Background</b>: The purpose of this study was to investigate the relationship between folic acid and iron nutrition during pregnancy and congenital heart disease (CHD) in the offspring. <b>Methods</b>: Conditional logistic regression models and nonlinear mixed-effects models were used to analyze the effects of folic acid and iron nutrition during pregnancy on CHD in offspring. <b>Results</b>: After adjusting for confounders, folic acid or iron supplementation during pregnancy reduced the risk for fetal CHD (<i>OR</i> = 0.60 (0.45, 0.82) or 0.36 (0.27, 0.48)). Similarly, dietary iron intake during pregnancy (≥29 mg/d) was associated with a reduced risk of fetal CHD (<i>OR</i> = 0.64 (0.46, 0.88)). Additionally, compared with women who only supplemented folic acid (<i>OR</i> = 0.59 (0.41,NutrientsThe Association of Folic Acid, Iron Nutrition during Pregnancy and Congenital Heart Disease in Northwestern China: A Matched Case-Control Study.PMC9657607821039248123001672174167Rong PXZhao DDQu PFDuan XYYan MXZhang RZhao YDang SNDang YSPei LLfalseThe Association of Folic Acid, Iron Nutrition during Pregnancy and Congenital Heart Disease in Northwestern China: A Matched Case-Control Study.<b>Background</b>: The purpose of this study was to investigate the relationship between folic acid and iron nutrition during pregnancy and congenital heart disease (CHD) in the offspring. <b>Methods</b>: Conditional logistic regression models and nonlinear mixed-effects models were used to analyze the effects of folic acid and iron nutrition during pregnancy on CHD in offspring. <b>Results</b>: After adjusting for confounders, folic acid or iron supplementation during pregnancy reduced the risk for fetal CHD (<i>OR</i> = 0.60 (0.45, 0.82) or 0.36 (0.27, 0.48)). Similarly, dietary iron intake during pregnancy (≥29 mg/d) was associated with a reduced risk of fetal CHD (<i>OR</i> = 0.64 (0.46, 0.88)). Additionally, compared with women who only supplemented folic acid (<i>OR</i> = 0.59 (0.41,2022-01-01T00:00:00Z2022 Oct2025-04-26T11:58:43.739Z2025-04-06T13:50:00.266ZS-EPMC96576073636480410.3390/nu14214541