{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Portefaix A"],"funding":["Joint Research Unit Hospices Civils de Lyon-bioMérieux","bioMérieux"],"pagination":["6563"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9657860"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(21)"],"pubmed_abstract":["The diagnosis of serious bacterial infection (SBI) in young febrile children remains challenging. This prospective, multicentre, observational study aimed to identify new protein marker combinations that can differentiate a bacterial infection from a viral infection in 983 children, aged 7 days-36 months, presenting with a suspected SBI at three French paediatric emergency departments. The blood levels of seven protein markers (CRP, PCT, IL-6, NGAL, MxA, TRAIL, IP-10) were measured at enrolment. The patients received the standard of care, blinded to the biomarker results. An independent adjudication committee assigned a bacterial vs. viral infection diagnosis based on clinical data, blinded to the biomarker results. Computational modelling was applied to the blood levels of the biomarkers "],"journal":["Journal of clinical medicine"],"pubmed_title":["Performance Evaluation of Host Biomarker Combinations for the Diagnosis of Serious Bacterial Infection in Young Febrile Children: A Double-Blind, Multicentre, Observational Study."],"pmcid":["PMC9657860"],"funding_grant_id":["N/A"],"pubmed_authors":["Ouziel A","Pons S","Ginhoux T","Gillet Y","Basmaci R","Generenaz L","Javouhey E","Rebaud P","Brengel-Pesce K","Portefaix A","Subtil F","Meunier B","Trouillet-Assant S","Delafay MC","Oriol G","Abbas-Chorfa F"],"additional_accession":[]},"is_claimable":false,"name":"Performance Evaluation of Host Biomarker Combinations for the Diagnosis of Serious Bacterial Infection in Young Febrile Children: A Double-Blind, Multicentre, Observational Study.","description":"The diagnosis of serious bacterial infection (SBI) in young febrile children remains challenging. This prospective, multicentre, observational study aimed to identify new protein marker combinations that can differentiate a bacterial infection from a viral infection in 983 children, aged 7 days-36 months, presenting with a suspected SBI at three French paediatric emergency departments. The blood levels of seven protein markers (CRP, PCT, IL-6, NGAL, MxA, TRAIL, IP-10) were measured at enrolment. The patients received the standard of care, blinded to the biomarker results. An independent adjudication committee assigned a bacterial vs. viral infection diagnosis based on clinical data, blinded to the biomarker results. Computational modelling was applied to the blood levels of the biomarkers ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-04-08T14:24:46.211Z","creation":"2025-04-06T01:50:45.043Z"},"accession":"S-EPMC9657860","cross_references":{"pubmed":["36362791"],"doi":["10.3390/jcm11216563"]}}