biostudies-literaturePortefaix AJoint Research Unit Hospices Civils de Lyon-bioMérieuxbioMérieux6563https://www.ebi.ac.uk/biostudies/studies/S-EPMC9657860biostudies-literatureUnknown11(21)The diagnosis of serious bacterial infection (SBI) in young febrile children remains challenging. This prospective, multicentre, observational study aimed to identify new protein marker combinations that can differentiate a bacterial infection from a viral infection in 983 children, aged 7 days-36 months, presenting with a suspected SBI at three French paediatric emergency departments. The blood levels of seven protein markers (CRP, PCT, IL-6, NGAL, MxA, TRAIL, IP-10) were measured at enrolment. The patients received the standard of care, blinded to the biomarker results. An independent adjudication committee assigned a bacterial vs. viral infection diagnosis based on clinical data, blinded to the biomarker results. Computational modelling was applied to the blood levels of the biomarkers Journal of clinical medicinePerformance Evaluation of Host Biomarker Combinations for the Diagnosis of Serious Bacterial Infection in Young Febrile Children: A Double-Blind, Multicentre, Observational Study.PMC9657860N/AOuziel APons SGinhoux TGillet YBasmaci RGenerenaz LJavouhey ERebaud PBrengel-Pesce KPortefaix ASubtil FMeunier BTrouillet-Assant SDelafay MCOriol GAbbas-Chorfa FfalsePerformance Evaluation of Host Biomarker Combinations for the Diagnosis of Serious Bacterial Infection in Young Febrile Children: A Double-Blind, Multicentre, Observational Study.The diagnosis of serious bacterial infection (SBI) in young febrile children remains challenging. This prospective, multicentre, observational study aimed to identify new protein marker combinations that can differentiate a bacterial infection from a viral infection in 983 children, aged 7 days-36 months, presenting with a suspected SBI at three French paediatric emergency departments. The blood levels of seven protein markers (CRP, PCT, IL-6, NGAL, MxA, TRAIL, IP-10) were measured at enrolment. The patients received the standard of care, blinded to the biomarker results. An independent adjudication committee assigned a bacterial vs. viral infection diagnosis based on clinical data, blinded to the biomarker results. Computational modelling was applied to the blood levels of the biomarkers 2022-01-01T00:00:00Z2022 Nov2026-04-08T14:24:46.211Z2025-04-06T01:50:45.043ZS-EPMC96578603636279110.3390/jcm11216563