biostudies-literatureKokkonen HSwedish Research Council6535https://www.ebi.ac.uk/biostudies/studies/S-EPMC9658375biostudies-literatureUnknown11(21)<h4>Background</h4>The increased comorbidity and mortality in rheumatoid arthritis (RA) patients are largely due to cardiovascular disease (CVD). Previously, we demonstrated increased frequencies of risk factors for CVD (elevated body mass index (BMI), elevated apoliprotein (Apo) B:ApoA1 ratio, and smoking) in pre-RA individuals compared with matched controls.<h4>Objectives</h4>Assess the impact of traditional CV risk factors present before the onset of RA on the risk of CV events (CVE) after diagnosis in comparison with matched controls.<h4>Methods</h4>A case-control study including 521 pre-symptomatic individuals and 1566 controls identified within the Health Surveys of the Medical Biobank was performed. CVD risk factors were hypertension, elevated ApoB:A1 ratio, BMI, diabetes, and smokiJournal of clinical medicineCardiovascular Risk Factors before Onset of Rheumatoid Arthritis Are Associated with Cardiovascular Events after Disease Onset: A Case-Control Study.PMC96583752018-02551Kokkonen HStenlund HRantapaa-Dahlqvist SJohansson LfalseCardiovascular Risk Factors before Onset of Rheumatoid Arthritis Are Associated with Cardiovascular Events after Disease Onset: A Case-Control Study.<h4>Background</h4>The increased comorbidity and mortality in rheumatoid arthritis (RA) patients are largely due to cardiovascular disease (CVD). Previously, we demonstrated increased frequencies of risk factors for CVD (elevated body mass index (BMI), elevated apoliprotein (Apo) B:ApoA1 ratio, and smoking) in pre-RA individuals compared with matched controls.<h4>Objectives</h4>Assess the impact of traditional CV risk factors present before the onset of RA on the risk of CV events (CVE) after diagnosis in comparison with matched controls.<h4>Methods</h4>A case-control study including 521 pre-symptomatic individuals and 1566 controls identified within the Health Surveys of the Medical Biobank was performed. CVD risk factors were hypertension, elevated ApoB:A1 ratio, BMI, diabetes, and smoki2022-01-01T00:00:00Z2022 Nov2025-04-25T23:24:17.931Z2025-04-06T09:23:25.546ZS-EPMC96583753636276310.3390/jcm11216535