{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Faria M"],"funding":["Fundação para a Ciência e Tecnologia","SPEDM/Merk"],"pagination":["5362"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9659096"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(21)"],"pubmed_abstract":["While most cases of differentiated thyroid carcinoma (DTC) are associated with a good prognosis, a significant number progress to advanced disease exhibiting aggressive clinical characteristics and often becoming refractory to radioactive iodine (RAI) treatment, the current gold-standard therapeutic option for metastatic disease. RAI-refractoriness is caused by defective functional expression of the sodium-iodide symporter (NIS), which is responsible for the active transport of iodide across the plasma membrane (PM) into thyroid follicles. NIS deficiency in these tumors often reflects a transcriptional impairment, but also its defective targeting and retention at the cells' PM. Using proteomics, we previously characterized an intracellular signaling pathway derived from SRC kinase that act"],"journal":["Cancers"],"pubmed_title":["Adherens Junction Integrity Is a Critical Determinant of Sodium Iodide Symporter Residency at the Plasma Membrane of Thyroid Cells."],"pmcid":["PMC9659096"],"funding_grant_id":["PD/BD/114388/2016","PTDC/BIAMOL/31787/2017","UID/MULTI/04046/2019","Limbert Merck/SPEDM -2021"],"pubmed_authors":["Bugalho MJ","Miranda M","Matos P","Silva AL","Faria M","Vareda J"],"additional_accession":[]},"is_claimable":false,"name":"Adherens Junction Integrity Is a Critical Determinant of Sodium Iodide Symporter Residency at the Plasma Membrane of Thyroid Cells.","description":"While most cases of differentiated thyroid carcinoma (DTC) are associated with a good prognosis, a significant number progress to advanced disease exhibiting aggressive clinical characteristics and often becoming refractory to radioactive iodine (RAI) treatment, the current gold-standard therapeutic option for metastatic disease. RAI-refractoriness is caused by defective functional expression of the sodium-iodide symporter (NIS), which is responsible for the active transport of iodide across the plasma membrane (PM) into thyroid follicles. NIS deficiency in these tumors often reflects a transcriptional impairment, but also its defective targeting and retention at the cells' PM. Using proteomics, we previously characterized an intracellular signaling pathway derived from SRC kinase that act","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-25T23:28:36.717Z","creation":"2025-04-06T09:21:23.633Z"},"accession":"S-EPMC9659096","cross_references":{"pubmed":["36358781"],"doi":["10.3390/cancers14215362"]}}