{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zavala VA"],"funding":["Eunice Kennedy Shriver National Institute of Child Health and Human Development","NICHD NIH HHS","National Cancer Institute","NCI NIH HHS"],"pagination":["1602-1609"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9662925"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(8)"],"pubmed_abstract":["Background
Breast cancer incidence in the United States is lower in Hispanic/Latina (H/L) compared with African American/Black or Non-Hispanic White women. An Indigenous American breast cancer-protective germline variant (rs140068132) has been reported near the estrogen receptor 1 gene. This study tests the association of rs140068132 and other polymorphisms in the 6q25 region with subtype-specific breast cancer risk in H/Ls of high Indigenous American ancestry.Methods
Genotypes were obtained for 5,094 Peruvian women with (1,755) and without (3,337) breast cancer. Associations between genotype and overall and subtype-specific risk for the protective variant were tested using logistic regression models and conditional analyses, including other risk-associated polymorphisms in"],"journal":["Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology"],"pubmed_title":["Association between Ancestry-Specific 6q25 Variants and Breast Cancer Subtypes in Peruvian Women."],"pmcid":["PMC9662925"],"funding_grant_id":["R01 HD059835","R01CA204797","R01-HD-059835","R01 CA204797"],"pubmed_authors":["Morante Z","Huntsman S","Gelaye B","Castaneda CA","Liendo-Picoaga R","Monge C","Galvez-Nino M","Navarro-Vasquez J","Vidaurre T","Calderon M","Ziv E","Cotrina JM","Godoy L","Dutil J","Zabaleta J","Abugattas JE","Fuentes HA","Williams MA","Sanchez SE","Zavala VA","Enriquez-Vera D","Vasquez J","Nunez-Marrero A","Olshen AB","Neciosup SP","Fejerman L","Hu D","Gomez H","Casavilca-Zambrano S","Valencia G","Hechmer A"],"additional_accession":[]},"is_claimable":false,"name":"Association between Ancestry-Specific 6q25 Variants and Breast Cancer Subtypes in Peruvian Women.","description":"Background
Breast cancer incidence in the United States is lower in Hispanic/Latina (H/L) compared with African American/Black or Non-Hispanic White women. An Indigenous American breast cancer-protective germline variant (rs140068132) has been reported near the estrogen receptor 1 gene. This study tests the association of rs140068132 and other polymorphisms in the 6q25 region with subtype-specific breast cancer risk in H/Ls of high Indigenous American ancestry.Methods
Genotypes were obtained for 5,094 Peruvian women with (1,755) and without (3,337) breast cancer. Associations between genotype and overall and subtype-specific risk for the protective variant were tested using logistic regression models and conditional analyses, including other risk-associated polymorphisms in","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-05-29T06:39:08.316Z","creation":"2025-04-06T00:53:09.353Z"},"accession":"S-EPMC9662925","cross_references":{"pubmed":["35654312"],"doi":["10.1158/1055-9965.EPI-22-0069"]}}