biostudies-literatureZavala VAEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNICHD NIH HHSNational Cancer InstituteNCI NIH HHS1602-1609https://www.ebi.ac.uk/biostudies/studies/S-EPMC9662925biostudies-literatureUnknown31(8)<h4>Background</h4>Breast cancer incidence in the United States is lower in Hispanic/Latina (H/L) compared with African American/Black or Non-Hispanic White women. An Indigenous American breast cancer-protective germline variant (rs140068132) has been reported near the estrogen receptor 1 gene. This study tests the association of rs140068132 and other polymorphisms in the 6q25 region with subtype-specific breast cancer risk in H/Ls of high Indigenous American ancestry.<h4>Methods</h4>Genotypes were obtained for 5,094 Peruvian women with (1,755) and without (3,337) breast cancer. Associations between genotype and overall and subtype-specific risk for the protective variant were tested using logistic regression models and conditional analyses, including other risk-associated polymorphisms inCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyAssociation between Ancestry-Specific 6q25 Variants and Breast Cancer Subtypes in Peruvian Women.PMC9662925R01 HD059835R01CA204797R01-HD-059835R01 CA204797Morante ZHuntsman SGelaye BCastaneda CALiendo-Picoaga RMonge CGalvez-Nino MNavarro-Vasquez JVidaurre TCalderon MZiv ECotrina JMGodoy LDutil JZabaleta JAbugattas JEFuentes HAWilliams MASanchez SEZavala VAEnriquez-Vera DVasquez JNunez-Marrero AOlshen ABNeciosup SPFejerman LHu DGomez HCasavilca-Zambrano SValencia GHechmer AfalseAssociation between Ancestry-Specific 6q25 Variants and Breast Cancer Subtypes in Peruvian Women.<h4>Background</h4>Breast cancer incidence in the United States is lower in Hispanic/Latina (H/L) compared with African American/Black or Non-Hispanic White women. An Indigenous American breast cancer-protective germline variant (rs140068132) has been reported near the estrogen receptor 1 gene. This study tests the association of rs140068132 and other polymorphisms in the 6q25 region with subtype-specific breast cancer risk in H/Ls of high Indigenous American ancestry.<h4>Methods</h4>Genotypes were obtained for 5,094 Peruvian women with (1,755) and without (3,337) breast cancer. Associations between genotype and overall and subtype-specific risk for the protective variant were tested using logistic regression models and conditional analyses, including other risk-associated polymorphisms in2022-01-01T00:00:00Z2022 Aug2026-05-29T06:39:08.316Z2025-04-06T00:53:09.353ZS-EPMC96629253565431210.1158/1055-9965.EPI-22-0069