{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kawanabe-Matsuda H"],"funding":["Japan Agency for Medical Research and Development","Ministry of Education, Culture, Sports, Science and Technology","National Health and Medical Research Council"],"pagination":["1336-1355"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9662940"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(5)"],"pubmed_abstract":["Microbes and their byproducts have been reported to regulate host health and immune functions. Here we demonstrated that microbial exopolysaccharide produced by Lactobacillus delbrueckii subsp. bulgaricus OLL1073R-1 (EPS-R1) induced CCR6+ CD8+ T cells of mice and humans. In mice, ingestion of EPS-R1 augmented antitumor effects of anti-CTLA-4 or anti-PD-1 monoclonal antibody against CCL20-expressing tumors, in which infiltrating CCR6+ CD8+ T cells were increased and produced IFNγ accompanied by a substantial immune response gene expression signature maintaining T-cell functions. Of note, the antitumor adjuvant effect of EPS-R1 was also observed in germ-free mice. Furthermore, the induction of CCR6 expression was mediated through the phosphorylated structure in EPS-R1 and a lysophosphatidic "],"journal":["Cancer discovery"],"pubmed_title":["Dietary Lactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy."],"pmcid":["PMC9662940"],"funding_grant_id":["1173958 and 1132519","15K14410","20gm0010004h9904","19H03366","18K19483 and 18H02695"],"pubmed_authors":["Okumura K","Nakamura M","Kano K","Eberl G","Kawanabe-Matsuda H","Nishimukai M","Makino S","Aoki J","Boneca IG","Ohno T","Uwamizu A","Omi J","Yagita H","Takeda K","Karasaki T","Kakimi K","Smyth MJ"],"additional_accession":[]},"is_claimable":false,"name":"Dietary Lactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy.","description":"Microbes and their byproducts have been reported to regulate host health and immune functions. Here we demonstrated that microbial exopolysaccharide produced by Lactobacillus delbrueckii subsp. bulgaricus OLL1073R-1 (EPS-R1) induced CCR6+ CD8+ T cells of mice and humans. In mice, ingestion of EPS-R1 augmented antitumor effects of anti-CTLA-4 or anti-PD-1 monoclonal antibody against CCL20-expressing tumors, in which infiltrating CCR6+ CD8+ T cells were increased and produced IFNγ accompanied by a substantial immune response gene expression signature maintaining T-cell functions. Of note, the antitumor adjuvant effect of EPS-R1 was also observed in germ-free mice. Furthermore, the induction of CCR6 expression was mediated through the phosphorylated structure in EPS-R1 and a lysophosphatidic ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-28T22:40:06.819Z","creation":"2025-04-04T20:21:48.002Z"},"accession":"S-EPMC9662940","cross_references":{"pubmed":["35180303"],"doi":["10.1158/2159-8290.CD-21-0929"]}}