biostudies-literatureWoo XYStand Up To CancerThe Jackson Laboratory Director's Innovation FundNational Cancer InstituteMaine Cancer FoundationNCI NIH HHSRobert J. Kleberg, Jr. and Helen C. Kleberg FoundationHope Foundation4126-4138https://www.ebi.ac.uk/biostudies/studies/S-EPMC9664138biostudies-literatureUnknown82(22)Patient-derived xenograft (PDX) models are an effective preclinical in vivo platform for testing the efficacy of novel drugs and drug combinations for cancer therapeutics. Here we describe a repository of 79 genomically and clinically annotated lung cancer PDXs available from The Jackson Laboratory that have been extensively characterized for histopathologic features, mutational profiles, gene expression, and copy-number aberrations. Most of the PDXs are models of non-small cell lung cancer (NSCLC), including 37 lung adenocarcinoma (LUAD) and 33 lung squamous cell carcinoma (LUSC) models. Other lung cancer models in the repository include four small cell carcinomas, two large cell neuroendocrine carcinomas, two adenosquamous carcinomas, and one pleomorphic carcinoma. Models with both de noCancer researchA Genomically and Clinically Annotated Patient-Derived Xenograft Resource for Preclinical Research in Non-Small Cell Lung Cancer.PMC9664138R01 CA089713P30 CA034196U10 CA1809445U01 CA180944U54 CA233306P30 CA093373201502309George JBult CJLara PNKaruturi RKMChavaree MLloyd MWWoo XYSrivastava AJocoy ELSanderson BJGrubb SCStafford GAOpenshaw THCheng MMack PCGraber JHGoodwin NHolland WTepper CGBundy MChen MTsai RANeuhauser SBPeterson JGAirhart SDGandour-Edwards RRiess JWSimons AKKeck JPaisie CGandara DRDomanskyi SLiu ETfalseA Genomically and Clinically Annotated Patient-Derived Xenograft Resource for Preclinical Research in Non-Small Cell Lung Cancer.Patient-derived xenograft (PDX) models are an effective preclinical in vivo platform for testing the efficacy of novel drugs and drug combinations for cancer therapeutics. Here we describe a repository of 79 genomically and clinically annotated lung cancer PDXs available from The Jackson Laboratory that have been extensively characterized for histopathologic features, mutational profiles, gene expression, and copy-number aberrations. Most of the PDXs are models of non-small cell lung cancer (NSCLC), including 37 lung adenocarcinoma (LUAD) and 33 lung squamous cell carcinoma (LUSC) models. Other lung cancer models in the repository include four small cell carcinomas, two large cell neuroendocrine carcinomas, two adenosquamous carcinomas, and one pleomorphic carcinoma. Models with both de no2022-01-01T00:00:00Z2022 Nov2026-06-03T18:38:04.805Z2025-04-04T23:45:20.11ZS-EPMC96641383606986610.1158/0008-5472.CAN-22-0948