{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Katanski CD"],"pubmed_abstract":["Emerging and re-emerging respiratory viruses can spread rapidly and cause pandemics as demonstrated by the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. The early human immune responses to respiratory viruses are in the nasal cavity and nasopharyngeal regions. Defining biomarkers of disease trajectory at the time of a positive diagnostic test would be an important tool to facilitate decisions such as initiation of antiviral treatment. We hypothesize that nasopharyngeal tRNA profiles could be used to predict Coronavirus Disease 19 (COVID-19) severity. We carried out multiplex small RNA sequencing (MSR-seq) on residual nasopharyngeal swabs to measure simultaneously full-length tRNA abundance, tRNA modifications, and tRNA fragmentation for the human tRNA respon"],"journal":["Frontiers in cell and developmental biology"],"pagination":["999351"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9664364"],"repository":["biostudies-literature"],"pubmed_title":["tRNA abundance, modification and fragmentation in nasopharyngeal swabs as biomarkers for COVID-19 severity."],"pmcid":["PMC9664364"],"pubmed_authors":["Pan T","Paniz-Mondolfi A","Alshammary H","Simon V","Lolans K","Huang S","Hernandez MM","Watkins CP","Gonzales-Reiche A","Polanco J","Mount Sinai PSP study group","Fabre S","Katanski CD","van Bakel H","Sordillo EM"],"additional_accession":[]},"is_claimable":false,"name":"tRNA abundance, modification and fragmentation in nasopharyngeal swabs as biomarkers for COVID-19 severity.","description":"Emerging and re-emerging respiratory viruses can spread rapidly and cause pandemics as demonstrated by the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. The early human immune responses to respiratory viruses are in the nasal cavity and nasopharyngeal regions. Defining biomarkers of disease trajectory at the time of a positive diagnostic test would be an important tool to facilitate decisions such as initiation of antiviral treatment. We hypothesize that nasopharyngeal tRNA profiles could be used to predict Coronavirus Disease 19 (COVID-19) severity. We carried out multiplex small RNA sequencing (MSR-seq) on residual nasopharyngeal swabs to measure simultaneously full-length tRNA abundance, tRNA modifications, and tRNA fragmentation for the human tRNA respon","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T18:57:25.414Z","creation":"2025-04-06T02:39:03.802Z"},"accession":"S-EPMC9664364","cross_references":{"pubmed":["36393870"],"doi":["10.3389/fcell.2022.999351"]}}