{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Szabo KF"],"funding":["Narodowe Centrum Nauki"],"pagination":["8120-8124"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9664488"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(44)"],"pubmed_abstract":["Despite the broad interest in organic compounds possessing a γ-aminocarbonyl motif, limited strategies for their synthesis have been reported. Herein, we describe a mild and efficient method for the site-selective amidation of unsaturated enones with electrophilic N-centered radicals as a key intermediate. The photocatalytic vinylogous reaction of dienolates with <i>N</i>-amino pyridinium salts affords γ-amido carbonyl compounds. This process is high-yielding, scalable, and tolerates a broad range of unsaturated α,β-unsaturated carbonyls, including biologically relevant compounds, as starting materials."],"journal":["Organic letters"],"pubmed_title":["Site-Selective, Photocatalytic Vinylogous Amidation of Enones."],"pmcid":["PMC9664488"],"funding_grant_id":["UMO-2020/38/A/ST4/00185","UMO-2019/32/T/ST4/00303"],"pubmed_authors":["Szabo KF","Szurmak J","Goliszewska K","Gryko D","Rybicka-Jasinska K"],"additional_accession":[]},"is_claimable":false,"name":"Site-Selective, Photocatalytic Vinylogous Amidation of Enones.","description":"Despite the broad interest in organic compounds possessing a γ-aminocarbonyl motif, limited strategies for their synthesis have been reported. Herein, we describe a mild and efficient method for the site-selective amidation of unsaturated enones with electrophilic N-centered radicals as a key intermediate. The photocatalytic vinylogous reaction of dienolates with <i>N</i>-amino pyridinium salts affords γ-amido carbonyl compounds. This process is high-yielding, scalable, and tolerates a broad range of unsaturated α,β-unsaturated carbonyls, including biologically relevant compounds, as starting materials.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-22T19:11:28.41Z","creation":"2025-04-06T02:39:41.113Z"},"accession":"S-EPMC9664488","cross_references":{"pubmed":["36327199"],"doi":["10.1021/acs.orglett.2c03161"]}}