biostudies-literatureSzabo KFNarodowe Centrum Nauki8120-8124https://www.ebi.ac.uk/biostudies/studies/S-EPMC9664488biostudies-literatureUnknown24(44)Despite the broad interest in organic compounds possessing a γ-aminocarbonyl motif, limited strategies for their synthesis have been reported. Herein, we describe a mild and efficient method for the site-selective amidation of unsaturated enones with electrophilic N-centered radicals as a key intermediate. The photocatalytic vinylogous reaction of dienolates with <i>N</i>-amino pyridinium salts affords γ-amido carbonyl compounds. This process is high-yielding, scalable, and tolerates a broad range of unsaturated α,β-unsaturated carbonyls, including biologically relevant compounds, as starting materials.Organic lettersSite-Selective, Photocatalytic Vinylogous Amidation of Enones.PMC9664488UMO-2020/38/A/ST4/00185UMO-2019/32/T/ST4/00303Szabo KFSzurmak JGoliszewska KGryko DRybicka-Jasinska KfalseSite-Selective, Photocatalytic Vinylogous Amidation of Enones.Despite the broad interest in organic compounds possessing a γ-aminocarbonyl motif, limited strategies for their synthesis have been reported. Herein, we describe a mild and efficient method for the site-selective amidation of unsaturated enones with electrophilic N-centered radicals as a key intermediate. The photocatalytic vinylogous reaction of dienolates with <i>N</i>-amino pyridinium salts affords γ-amido carbonyl compounds. This process is high-yielding, scalable, and tolerates a broad range of unsaturated α,β-unsaturated carbonyls, including biologically relevant compounds, as starting materials.2022-01-01T00:00:00Z2022 Nov2025-04-22T19:11:28.41Z2025-04-06T02:39:41.113ZS-EPMC96644883632719910.1021/acs.orglett.2c03161