{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(1)"],"submitter":["Norouzian M"],"pubmed_abstract":["<h4>Background</h4>A crucial role for the immune system has been proposed in the establishment and progression of head and neck squamous cell carcinoma (HNSCC). In this study, we investigated the cytokine and regulatory profiles of T cells in tumor draining lymph nodes (TDLNs) of patients with HNSCC.<h4>Results</h4>The frequencies of CD4<sup>+</sup>TNF-α<sup>+</sup> and CD4<sup>+</sup>TNF-α<sup>hi</sup> negatively were associated with poor prognostic factors such as LN involvement (P = 0.015 and P = 0.019, respectively), stage of the disease (P = 0.032 and P = 0.010, respectively) and tumor size (P = 0.026 and P = 0.032, respectively). Frequencies of CD8<sup>+</sup>IFN-γ<sup>+</sup> and CD8<sup>+</sup>IFN-γ<sup>+</sup> TNF-α<sup>+</sup> T cells showed negative relationship with tumor grade"],"journal":["BMC immunology"],"pagination":["56"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9664675"],"repository":["biostudies-literature"],"pubmed_title":["Regulatory and effector T cell subsets in tumor-draining lymph nodes of patients with squamous cell carcinoma of head and neck."],"pmcid":["PMC9664675"],"pubmed_authors":["Norouzian M","Mehdipour F","Ashraf MJ","Ghaderi A","Khademi B"],"additional_accession":[]},"is_claimable":false,"name":"Regulatory and effector T cell subsets in tumor-draining lymph nodes of patients with squamous cell carcinoma of head and neck.","description":"<h4>Background</h4>A crucial role for the immune system has been proposed in the establishment and progression of head and neck squamous cell carcinoma (HNSCC). In this study, we investigated the cytokine and regulatory profiles of T cells in tumor draining lymph nodes (TDLNs) of patients with HNSCC.<h4>Results</h4>The frequencies of CD4<sup>+</sup>TNF-α<sup>+</sup> and CD4<sup>+</sup>TNF-α<sup>hi</sup> negatively were associated with poor prognostic factors such as LN involvement (P = 0.015 and P = 0.019, respectively), stage of the disease (P = 0.032 and P = 0.010, respectively) and tumor size (P = 0.026 and P = 0.032, respectively). Frequencies of CD8<sup>+</sup>IFN-γ<sup>+</sup> and CD8<sup>+</sup>IFN-γ<sup>+</sup> TNF-α<sup>+</sup> T cells showed negative relationship with tumor grade","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-19T13:21:54.742Z","creation":"2025-04-19T13:21:54.742Z"},"accession":"S-EPMC9664675","cross_references":{"pubmed":["36376825"],"doi":["10.1186/s12865-022-00530-3"]}}