{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["66(11)"],"submitter":["Faccone D"],"pubmed_abstract":["A ceftazidime-avibactam-resistant KPC-producing Pseudomonas aeruginosa strain was isolated in Argentina from a tracheal aspirate. The patient was treated with ceftazidime-avibactam in combination with other agents for 130 days. Whole-genome sequencing of P. aeruginosa identified a D179Y substitution in the Ω loop of KPC-3, corresponding to KPC-31, integrated at the chromosome. The strain belonged to the sequence type 235/O11 (ST235/O11) high-risk clone. Evaluation of carbapenemase detection assays most used by clinical laboratories failed to identify the isolate as a KPC producer."],"journal":["Antimicrobial agents and chemotherapy"],"pagination":["e0064822"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9664854"],"repository":["biostudies-literature"],"pubmed_title":["Emergence of KPC-31, a KPC-3 Variant Associated with Ceftazidime-Avibactam Resistance, in an Extensively Drug-Resistant ST235 Pseudomonas aeruginosa Clinical Isolate."],"pmcid":["PMC9664854"],"pubmed_authors":["Albornoz E","Seah C","Melano RG","Mora A","Corso A","Echegorry M","Ceriana P","Chavez M","Genero F","Pasteran F","de Mendieta JM","Faccone D"],"additional_accession":[]},"is_claimable":false,"name":"Emergence of KPC-31, a KPC-3 Variant Associated with Ceftazidime-Avibactam Resistance, in an Extensively Drug-Resistant ST235 Pseudomonas aeruginosa Clinical Isolate.","description":"A ceftazidime-avibactam-resistant KPC-producing Pseudomonas aeruginosa strain was isolated in Argentina from a tracheal aspirate. The patient was treated with ceftazidime-avibactam in combination with other agents for 130 days. Whole-genome sequencing of P. aeruginosa identified a D179Y substitution in the Ω loop of KPC-3, corresponding to KPC-31, integrated at the chromosome. The strain belonged to the sequence type 235/O11 (ST235/O11) high-risk clone. Evaluation of carbapenemase detection assays most used by clinical laboratories failed to identify the isolate as a KPC producer.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-26T13:13:12.768Z","creation":"2025-04-06T14:09:48.664Z"},"accession":"S-EPMC9664854","cross_references":{"pubmed":["36286541"],"doi":["10.1128/aac.00648-22"]}}