{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Long S"],"pubmed_abstract":["5-Fluorouracil (5-FU) chemoresistance is a persistent impediment to the efficient treatment of many types of cancer, yet the molecular mechanisms underlying such resistance remain incompletely understood. Here we found CRC patients resistant to 5-FU treatment exhibited increased extracellular matrix protein 1 (ECM1) expression compared to CRC patients sensitive to this chemotherapeutic agent, and higher levels of ECM1 expression were correlated significantly with shorter overall survival and disease-free survival. 5-FU resistant HCT15 (HCT15/FU) cells expressed significantly higher levels of ECM1 relative to parental HCT15 cells. Changes in ECM1 expression altered the ability of both parental and HCT15/FU cells to tolerate the medication <i>in vitro</i> and <i>in vivo via</i> processes ass"],"journal":["Frontiers in pharmacology"],"pagination":["1005915"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9666402"],"repository":["biostudies-literature"],"pubmed_title":["ECM1 regulates the resistance of colorectal cancer to 5-FU treatment by modulating apoptotic cell death and epithelial-mesenchymal transition induction."],"pmcid":["PMC9666402"],"pubmed_authors":["Weng F","Zhou S","Xiang D","Pei Z","Sun G","Wang J","Long S"],"additional_accession":[]},"is_claimable":false,"name":"ECM1 regulates the resistance of colorectal cancer to 5-FU treatment by modulating apoptotic cell death and epithelial-mesenchymal transition induction.","description":"5-Fluorouracil (5-FU) chemoresistance is a persistent impediment to the efficient treatment of many types of cancer, yet the molecular mechanisms underlying such resistance remain incompletely understood. Here we found CRC patients resistant to 5-FU treatment exhibited increased extracellular matrix protein 1 (ECM1) expression compared to CRC patients sensitive to this chemotherapeutic agent, and higher levels of ECM1 expression were correlated significantly with shorter overall survival and disease-free survival. 5-FU resistant HCT15 (HCT15/FU) cells expressed significantly higher levels of ECM1 relative to parental HCT15 cells. Changes in ECM1 expression altered the ability of both parental and HCT15/FU cells to tolerate the medication <i>in vitro</i> and <i>in vivo via</i> processes ass","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T10:41:14.068Z","creation":"2025-04-19T10:41:14.068Z"},"accession":"S-EPMC9666402","cross_references":{"pubmed":["36408224"],"doi":["10.3389/fphar.2022.1005915"]}}