biostudies-literatureUnknown4(19)Tawney AMWe report a patient with severe mitral annular calcification, mitral stenosis/regurgitation, hypertrophic obstructive cardiomyopathy, and subaortic membrane treated with valved left atrium-left ventricle conduit, septal myectomy, and membrane resection. Subsequent thrombosis of the conduit prompted successful valve-in- mitral annular calcification transcatheter mitral valve replacement and laceration of the anterior mitral leaflet to prevent outflow obstruction. (<b>Level of Difficulty: Advanced.</b>).JACC. Case reports1267-1273https://www.ebi.ac.uk/biostudies/studies/S-EPMC9666751biostudies-literatureValve-in-Mitral Annular Calcification Transcatheter Mitral Valve Replacement After Thrombosis of Extracardiac Valved Conduit.PMC9666751Schott JPTawney AMAbbas AEHanson IDSafian RDO'Connell TFBilolikar ANRenard BMGoldstein JABloomingdale RJfalseValve-in-Mitral Annular Calcification Transcatheter Mitral Valve Replacement After Thrombosis of Extracardiac Valved Conduit.We report a patient with severe mitral annular calcification, mitral stenosis/regurgitation, hypertrophic obstructive cardiomyopathy, and subaortic membrane treated with valved left atrium-left ventricle conduit, septal myectomy, and membrane resection. Subsequent thrombosis of the conduit prompted successful valve-in- mitral annular calcification transcatheter mitral valve replacement and laceration of the anterior mitral leaflet to prevent outflow obstruction. (<b>Level of Difficulty: Advanced.</b>).2022-01-01T00:00:00Z2022 Oct2025-04-21T14:17:26.997Z2025-04-21T14:17:26.997ZS-EPMC96667513640692110.1016/j.jaccas.2022.07.024